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Literature DB >> 4291255

Enzymatic synthesis of cytidine diphosphate diglyceride.

Abstract

Evidence is presented for the enzymatic formation of cytidine diphosphate diglyceride in microsomal preparations from guinea pig liver according to the reaction: CTP + phosphatidic acid right harpoon over left harpoon CDP-diglyceride + p-O-P. Conditions have been found in which the incorporation of labeled CTP into CDP-diglyceride is almost entirely dependent upon added phosphatidic acid. The incorporation of CMP into lipid is very slight. A substantial net synthesis of CDP-diglyceride takes place under these conditions. Some properties of the enzyme system are described.

Entities: Chemical Species

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Year: 1966 PMID： 4291255

Source DB: PubMed Journal: J Lipid Res ISSN： 0022-2275 Impact factor: 5.922

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Cited

39 in total

1. CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulum.

Authors: Mark G Waugh; Shane Minogue; Emma L Clayton; J Justin Hsuan
Journal: J Lipid Res Date: 2011-09-21 Impact factor: 5.922

Review 2. Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae.

Authors: George M Carman; Gil-Soo Han
Journal: Annu Rev Biochem Date: 2011 Impact factor: 23.643

3. Biosynthesis of cytidine diphosphate diglyceride by cauliflower mitochondria.

Authors: S Sumida; J B Mudd
Journal: Plant Physiol Date: 1968-07 Impact factor: 8.340

4. Role of cytidine triphosphate and cytidine diphosphate in promoting inositol entry into microsomal phosphatidylinositol.

Authors: B J Holub
Journal: Lipids Date: 1975-08 Impact factor: 1.880

5. The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.

Authors: Steve Poirier; Samaneh Samami; Maya Mamarbachi; Annie Demers; Ta Yuan Chang; Dennis E Vance; Grant M Hatch; Gaétan Mayer
Journal: J Biol Chem Date: 2014-05-22 Impact factor: 5.157

6. Impaired photosynthesis in phosphatidylglycerol-deficient mutant of cyanobacterium Anabaena sp. PCC7120 with a disrupted gene encoding a putative phosphatidylglycerophosphatase.

Authors: Feng Wu; Zhenle Yang; Tingyun Kuang
Journal: Plant Physiol Date: 2006-06-30 Impact factor: 8.340

Enzymatic synthesis of cytidine diphosphate diglyceride.

1. CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulum.

Review 2. Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae.

3. Biosynthesis of cytidine diphosphate diglyceride by cauliflower mitochondria.

4. Role of cytidine triphosphate and cytidine diphosphate in promoting inositol entry into microsomal phosphatidylinositol.

5. The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.

6. Impaired photosynthesis in phosphatidylglycerol-deficient mutant of cyanobacterium Anabaena sp. PCC7120 with a disrupted gene encoding a putative phosphatidylglycerophosphatase.

7. Regulation of phosphatidate phosphatase activity by inositol in Saccharomyces cerevisiae.

8. Biosynthesis of cytidine diphosphate diglyceride by enzyme preparations from cauliflower.

9. Stimulation of phosphatidylglycerolphosphate phosphatase activity by unsaturated fatty acids in rat heart.

10. Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.