Literature DB >> 4288164

Pituitary tumors in mice after prolonged feeding of synthetic progestins.

W E Poel.   

Abstract

An enhanced development of pituitary tumors was observed in virgin female mice of the C57 Leaden strain following repeated oral administration of synthetic progestins. This finding appears to parallel the co-carcinogenic enhancement of mammary tumor development elicited in C3H mice treated repeatedly with progesterone.

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Year:  1966        PMID： 4288164     DOI： 10.1126/science.154.3747.402

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Cancer hazards of the pharmacy.

Authors:  G M Bonser
Journal:  Br Med J       Date:  1967-10-28

2.  Enhanced LH action in transgenic female mice expressing hCGbeta-subunit induces pituitary prolactinomas; the role of high progesterone levels.

Authors:  Petteri Ahtiainen; Victoria Sharp; Susana B Rulli; Adolfo Rivero-Müller; Veronika Mamaeva; Matias Röyttä; Ilpo Huhtaniemi
Journal:  Endocr Relat Cancer       Date:  2010-06-03       Impact factor: 5.678

3.  Progesterone enhancement of mammary tumor development as a model of co-carcinogenesis.

Authors:  W E Poel
Journal:  Br J Cancer       Date:  1968-12       Impact factor: 7.640

4.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031
  4 in total

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