| Literature DB >> 4288079 |
F L Margolis, J Roffi, A Jost.
Abstract
The activity of phenylethanolamine-N-methyl transferase, the enzyme that methylates norepinephrine to form epinephrine, increases rapidly in the fetal rat adrenal during the day preceding epinephrine accumulation. The developmental increase in enzyme activity and the accumulation of epinephrine are prevented by fetal hypophysectomy (decapitation). Administration of adrenocorticotrophic hormone or cortisol acetate largely reverses the effect of fetal decapitation.Entities:
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Year: 1966 PMID： 4288079 DOI： 10.1126/science.154.3746.275
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728