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Literature DB >> 428149

Levels of the serum amyloid A protein (SAA) in normal persons of different age groups.

Abstract

Serum amyloid A (SAA) has been implicated by three independent studies to increase in concentration with ageing. The present study measured SAA concentration in 395 samples from 302 healthy individuals ranging in age from 21 to 100 years. The average SAA concentration was 20 microgram/ml, with only five serum samples falling below 5 microgram/ml. SAA concentrations are expressed in terms of cross-reactivity of purified, denatured SAA with anti-AA antibodies, rather than the purified, denatured amyloid fibril protein AA from tissues, which has been used in the past. No age-related increase in SAA concentration was observed in the present study. The average SAA concentration in these normal, healthy individuals was almost a hundred-fold less than values measured in acute phase human serum in a separate study with the same reagents.

Entities: Gene Species

Mesh：

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Year: 1979 PMID： 428149 PMCID： PMC1537586

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

14 in total

1. Conformational flexibility of the serum amyloid precursor SAA.

Authors: J D Sipe; K P McAdam; B F Torain; G G Glenner
Journal: Br J Exp Pathol Date: 1976-10

2. Murine amyloidosis: immunologic characterization of amyloid fibril protein.

Authors: C Isersky; D L Page; P Cuatrecasas; R A DeLellis; G G Glenner
Journal: J Immunol Date: 1971-12 Impact factor: 5.422

3. Immunochemical studies on the nature of the serum component (SAA) related to secondary amyloidosis.

Authors: T F Ignaczak; J D Sipe; F P Linke; G G Glenner
Journal: J Lab Clin Med Date: 1977-05

Review 4. Amyloid, amyloidosis, and amyloidogenesis.

Authors: G G Glenner; D L Page
Journal: Int Rev Exp Pathol Date: 1976

5. Isolation and structural properties of murine SAA--the acute phase serum precursor of amyloid AA.

Authors: J D Sipe; K P McAdam; B F Torain; P S Pollock
Journal: Immunol Commun Date: 1977

6. Changes in human serum amyloid A and C-reactive protein after etiocholanolone-induced inflammation.

Authors: K P McAdam; R J Elin; J D Sipe; S M Wolff
Journal: J Clin Invest Date: 1978-02 Impact factor: 14.808

7. Amyloid protein SAA is associated with high density lipoprotein from human serum.

Authors: E P Benditt; N Eriksen
Journal: Proc Natl Acad Sci U S A Date: 1977-09 Impact factor: 11.205

8. Variation with age and disease of an amyloid A protein-related serum component.

Authors: C J Rosenthal; E C Franklin
Journal: J Clin Invest Date: 1975-04 Impact factor: 14.808

9. Secretion of unconjugated androgens and estrogens by the normal and abnormal human testis before and after human chorionic gonadotropin.

Authors: R L Weinstein; R P Kelch; M R Jenner; S L Kaplan; M M Grumbach
Journal: J Clin Invest Date: 1974-01 Impact factor: 14.808

10. Characterization of human amyloid-related protein SAA as a polymorphic protein: association with albumin and prealbumin in serum.

Authors: G Marhaug; G Husby
Journal: Clin Exp Immunol Date: 1981-07 Impact factor: 4.330

Levels of the serum amyloid A protein (SAA) in normal persons of different age groups.

1. Conformational flexibility of the serum amyloid precursor SAA.

2. Murine amyloidosis: immunologic characterization of amyloid fibril protein.

3. Immunochemical studies on the nature of the serum component (SAA) related to secondary amyloidosis.

Review 4. Amyloid, amyloidosis, and amyloidogenesis.

5. Isolation and structural properties of murine SAA--the acute phase serum precursor of amyloid AA.

6. Changes in human serum amyloid A and C-reactive protein after etiocholanolone-induced inflammation.

7. Amyloid protein SAA is associated with high density lipoprotein from human serum.

8. Variation with age and disease of an amyloid A protein-related serum component.

9. Secretion of unconjugated androgens and estrogens by the normal and abnormal human testis before and after human chorionic gonadotropin.

10. Connective tissue origin of the amyloid-related protein SAA.

1. Isolation and characterization of the amyloid-related apoprotein (SAA) from human high density lipoprotein.

2. [New aspects of amyloidosis (author's transl)].

3. Serum amyloid a protein in clinical cancer diagnosis.

4. Transmissibility of systemic amyloidosis by a prion-like mechanism.

5. Amyloid protein SAA is an apoprotein of mouse plasma high density lipoprotein.

6. Monoclonal hybridoma antibodies to human amyloid related protein SAA.

7. Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils and protein A amyloid fibrils.

8. Comparison of serum amyloid A protein and C-reactive protein concentrations in cancer and non-malignant disease.

Review 9. Serum amyloid A: an acute-phase protein involved in tumour pathogenesis.

10. Characterization of human amyloid-related protein SAA as a polymorphic protein: association with albumin and prealbumin in serum.