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Literature DB >> 427793

Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines.

J C Barrett, B D Crawford, L O Mixter, L M Schechtman, P O Ts'o, R Pollack.

Abstract

Several in vitro phenotypic characteristics frequently associated with neoplastic cells were examined in a series of spontaneous and benzo(a)pyrene-induced Syrian hamster clonal cell lines which differed in their degree of tumorigenicity. Nonparametric statistical analysis demonstrated cloning efficiency in semisolid agar, enhanced fibrinolytic activity, decreased serum requirement for growth, decreased organization of intracellular actin, and increased cloning efficiency in liquid medium to be correlated with tumorigenicity. These correlations were not only qualitative but also quantitative. This suggests that the factors determining the degree of tumorigenicity of a cell can be cellular growth properties.

Entities: Chemical Species

Mesh：

Substances：
Actins
Culture Media

Year: 1979 PMID： 427793

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

28 in total

1. Two classes of continuous cell lines established from Syrian hamster 9 day gestation embryos: preneoplastic cells and progenitor cells.

Authors: T Okeda; Y Yokogawa; H Ueo; M A Bury; P O Ts'o; S A Bruce
Journal: In Vitro Cell Dev Biol Date: 1990-12

2. Studies of the T1 and T2 of intracellular water as a function of frequency in normal and transformed fetal cells.

Authors: D E Callahan; T L Trapane; S F Deamond; G Kao; P O Ts'o; L S Kan
Journal: Cell Biophys Date: 1991-06

3. NMR relaxation study of water protons in Syrian hamster fetal cells at 300 MHz.

Authors: W J Xin; S A Bruce; S F Deamond; L S Kan; J Honarbakhsh; P O Ts'o
Journal: Cell Biophys Date: 1986-06

4. Enhanced anchorage independent colony formation at increased agar concentrations in malignant mouse epithelial cell lines.

Authors: J M Bentel; G J Smith
Journal: In Vitro Cell Dev Biol Date: 1990-02

9. In vivo selection of tumorigenic subline from non-tumorigenic human gastric carcinoma cells: in relation to proliferative properties in vivo and in nude mice.

Authors: H Kubota; T Harada; S Morikawa; T Nakamura
Journal: Gastroenterol Jpn Date: 1988-08

10. Nonlytic simian virus 40-specific 100K phosphoprotein is associated with anchorage-independent growth in simian virus 40-transformed and revertant mouse cell lines.

Authors: S Chen; M Verderame; A Lo; R Pollack
Journal: Mol Cell Biol Date: 1981-11 Impact factor: 4.272

Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines.

1. Two classes of continuous cell lines established from Syrian hamster 9 day gestation embryos: preneoplastic cells and progenitor cells.

2. Studies of the T1 and T2 of intracellular water as a function of frequency in normal and transformed fetal cells.

3. NMR relaxation study of water protons in Syrian hamster fetal cells at 300 MHz.

4. Enhanced anchorage independent colony formation at increased agar concentrations in malignant mouse epithelial cell lines.

5. Neoplastic expression in murine cells induced by halogenated hydrocarbons.

6. Loss of tumor-suppressive function during chemically induced neoplastic progression of Syrian hamster embryo cells.

7. E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity.

8. Polyoma virus mutant with normal transforming ability but impaired tumorigenic potential.

9. In vivo selection of tumorigenic subline from non-tumorigenic human gastric carcinoma cells: in relation to proliferative properties in vivo and in nude mice.

10. Nonlytic simian virus 40-specific 100K phosphoprotein is associated with anchorage-independent growth in simian virus 40-transformed and revertant mouse cell lines.