Literature DB >> 427775

Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).

G L Neil, A E Berger, R P McPartland, G B Grindey, A Bloch.   

Abstract

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Year:  1979        PMID： 427775

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


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  6 in total

1.  Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness.

Authors:  A Hofer; D Steverding; A Chabes; R Brun; L Thelander
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

2.  Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.

Authors:  B Ardalan; B Chandrasekaran; H J Hrishikeshavan
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

3.  Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.

Authors:  Tobias T Schmidt; Gloria Reyes; Kerstin Gries; Cemile Ümran Ceylan; Sushma Sharma; Matthias Meurer; Michael Knop; Andrei Chabes; Hans Hombauer
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-17       Impact factor: 11.205

4.  Protease-activated "prodrugs" for cancer chemotherapy.

Authors:  P L Carl; P K Chakravarty; J A Katzenellenbogen; M J Weber
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

5.  Inhibition of gamma-glutamyl transpeptidase and induction of glutathionuria by gamma-glutamyl amino acids.

Authors:  M E Anderson; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

6.  Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition†Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. See DOI: 10.1039/c4sc02339k.

Authors:  Johannes Kreuzer; Nina C Bach; Daniel Forler; Stephan A Sieber
Journal:  Chem Sci       Date:  2014-09-26       Impact factor: 9.825
  6 in total

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