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Literature DB >> 4275942

Localization of five antibiotic resistances at the subunit level in chloroplast ribosomes of Chlamydomonas.

Abstract

The chloroplast ribosomes from five antibiotic resistant strains of Chlamydomonas, each carrying one mutant gene mapping in chloroplast DNA, have been shown to be resistant to the corresponding antibiotic in a poly(U)-directed amino-acid incorporating assay system. The alteration conferring resistance was localized to the 30S subunit in ribosomes from streptomycin, neamine, and spectinomycin resistant strains, and to the 50S subunit in ribosomes from cleocin and carbomycin resistant strains. Spectinomycin resistant ribosomes showed no cross-resistance to any other drugs, but limited cross-resistance was noted with the other mutant ribosomes. The similarity between these findings and results reported by others with bacterial ribosomes supports our hypothesis that at least some chloroplast ribosomal proteins are coded by genes in chloroplast DNA.

Entities: Chemical Species

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Year: 1974 PMID： 4275942 PMCID： PMC388309 DOI： 10.1073/pnas.71.5.1715

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

1. Ribosomal proteins. XXVII. Localization of the amino acid exchanges in protein S5 from two Escherichia coli mutants resistant to spectinomycin.

Authors: G Funatsu; E Schiltz; H G Wittmann
Journal: Mol Gen Genet Date: 1972

2. Biogenesis of mitochondria. 22. The sensitivity of rat liver mitochondria to antibiotics; a phylogenetic difference between a mammalian system and yeast.

Authors: N R Towers; H Dixon; G M Kellerman; A W Linnane
Journal: Arch Biochem Biophys Date: 1972-08 Impact factor: 4.013

3. Mutations altering chloroplast ribosome phenotype in Chlamydomonas. I. Non-mendelian mutations.

Authors: N W Gillham; J E Boynton; B Burkholder
Journal: Proc Natl Acad Sci U S A Date: 1970-10 Impact factor: 11.205

4. Characterization of the chloroplastic and cytoplasmic ribosomes of Chlamydomonas reinhardi.

Authors: J K Hoober; G Blobel
Journal: J Mol Biol Date: 1969-04-14 Impact factor: 5.469

5. A genetic map of non-Mandelian genes in Chlamydomonas.

Authors: R Sager; Z Ramanis
Journal: Proc Natl Acad Sci U S A Date: 1970-03 Impact factor: 11.205

6. Genetic mapping of aminoglycoside and fusidic acid resistant mutations in Bacillus subtilis.

Authors: C Goldthwaite; I Smith
Journal: Mol Gen Genet Date: 1972

7. Cytoplasmic and chloroplast ribosomes of Chlamydomonas: ultracentrifugal characterization.

Authors: R Sager; M G Hamilton
Journal: Science Date: 1967-08-11 Impact factor: 47.728

8. Peptide analyses of a protein component, 50-8, of 50s ribosomal subunit from erythromycin resistant mutants of Escherichia coli and Escherichia freudii.

Authors: E Otaka; T Itoh; S Osawa; K Tanaka; M Tamaki
Journal: Mol Gen Genet Date: 1972

9. Mendelian and uniparental alterations in erythromycin binding by plastid ribosomes.

Authors: L J Mets; L Bogorad
Journal: Science Date: 1971-11-12 Impact factor: 47.728

10. Studies on the structure and cellular location of various ribosome and ribosomal RNA species in the green alga Chlamydomonas reinhardi.

Authors: D P Bourque; J E Boynton; N W Gillham
Journal: J Cell Sci Date: 1971-01 Impact factor: 5.285

16 in total

8. Antibiotic resistance mutations in the chloroplast 16S and 23S rRNA genes of Chlamydomonas reinhardtii: correlation of genetic and physical maps of the chloroplast genome.

Authors: E H Harris; B D Burkhart; N W Gillham; J E Boynton
Journal: Genetics Date: 1989-10 Impact factor: 4.562

9. Erythromycin resistance and the chloroplast ribosome in Chlamydomonas reinhardi.

Authors: J N Davidson; M R Hanson; L Bogorad
Journal: Genetics Date: 1978-06 Impact factor: 4.562

10. Nuclear mutation increases streptomycin and spectinomycin sensitivity in Chlamydomonas.

Authors: R W Lee; J A Sapp
Journal: Genetics Date: 1978-04 Impact factor: 4.562

Localization of five antibiotic resistances at the subunit level in chloroplast ribosomes of Chlamydomonas.

1. Ribosomal proteins. XXVII. Localization of the amino acid exchanges in protein S5 from two Escherichia coli mutants resistant to spectinomycin.

2. Biogenesis of mitochondria. 22. The sensitivity of rat liver mitochondria to antibiotics; a phylogenetic difference between a mammalian system and yeast.

3. Mutations altering chloroplast ribosome phenotype in Chlamydomonas. I. Non-mendelian mutations.

4. Characterization of the chloroplastic and cytoplasmic ribosomes of Chlamydomonas reinhardi.

5. A genetic map of non-Mandelian genes in Chlamydomonas.

6. Genetic mapping of aminoglycoside and fusidic acid resistant mutations in Bacillus subtilis.

7. Cytoplasmic and chloroplast ribosomes of Chlamydomonas: ultracentrifugal characterization.

8. Peptide analyses of a protein component, 50-8, of 50s ribosomal subunit from erythromycin resistant mutants of Escherichia coli and Escherichia freudii.

9. Mendelian and uniparental alterations in erythromycin binding by plastid ribosomes.

10. Studies on the structure and cellular location of various ribosome and ribosomal RNA species in the green alga Chlamydomonas reinhardi.

1. Chloroplast genetics of chlamydomonas. I. Allelic segregation ratios.

2. Protein deficient chloroplast ribosomes in a yellow mutant of Chlamydomonas reinhardii.

3. Regulation of nuclear DNA replication by thechloroplast in Chlamydomonas.

4. Mutations that alter the transmission of chloroplast genes in Chlamydomonas.

5. Altered chloroplast ribosomal proteins in a yellow mutant of Chlamydomonas reinhardii.

6. Cytoplasmic and nuclear mutations to chloramphenicol resistance in Aspergillus nidulans.

7. Suppression of erythromycin resistance in ery-M1 mutants of Chlamydomonas reinhardi.

8. Antibiotic resistance mutations in the chloroplast 16S and 23S rRNA genes of Chlamydomonas reinhardtii: correlation of genetic and physical maps of the chloroplast genome.

9. Erythromycin resistance and the chloroplast ribosome in Chlamydomonas reinhardi.

10. Nuclear mutation increases streptomycin and spectinomycin sensitivity in Chlamydomonas.