Literature DB >> 4274968

In vitro antibacterial activity of spectinomycin.

I I Washington JA, P K Yu.   

Abstract

The in vitro inhibitory and bactericidal activities of spectinomycin hydrochloride were tested against a variety of bacteria. The antibiotic was inhibitory at 31.2 mug/ml to most strains of Escherichia coli, Klebsiella, Enterobacter, and Staphylococcus epidermidis. Concentrations of antibiotic exhibiting bactericidal activity exceeded the inhibitory concentration by at least fourfold. Regression graphs were plotted for results obtained with 30-, 100-, 200-, and 300-mug spectinomycin discs; tentative interpretative standards are proposed.

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Year:  1972        PMID： 4274968      PMCID： PMC444334          DOI： 10.1128/AAC.2.6.427

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  The usefulness of in vitro sensitivity tests in antibiotic therapy.

Authors:  R G PETERSDORF; J J PLORDE
Journal:  Annu Rev Med       Date:  1963       Impact factor: 13.739

2.  The mutual effects of antimicrobial compounds and metallic cations.

Authors:  E D WEINBERG
Journal:  Bacteriol Rev       Date:  1957-03

3.  Reversal of the antibacterial activity of polymyxin by divalent cations.

Authors:  B A NEWTON
Journal:  Nature       Date:  1953-07-25       Impact factor: 49.962

4.  Absorption, distribution, and elimination of spectinomycin dihydrochloride in man.

Authors:  J G Wagner; E Novak; L G Leslie; C M Metzler
Journal:  Int Z Klin Pharmakol Ther Toxikol       Date:  1968-04

5.  The treatment of gonorrhea with spectinomycin and rifampicin.

Authors:  R Labowitz; W L Porter; W J Holloway
Journal:  Del Med J       Date:  1970-11

6.  In vitro susceptibility of staphylococci and streptococci and influence of agar media on minimum inhibitory concentration.

Authors:  J A Washington; P E Hermans; W J Martin
Journal:  Mayo Clin Proc       Date:  1970-07       Impact factor: 7.616

7.  Antibiotic susceptibility testing by a standardized single disk method.

Authors:  A W Bauer; W M Kirby; J C Sherris; M Turck
Journal:  Am J Clin Pathol       Date:  1966-04       Impact factor: 2.493

8.  In vitro susceptibility of gram-negative bacilli to gentamicin.

Authors:  J A Washington; R E Ritts; W J Martin
Journal:  Mayo Clin Proc       Date:  1970-02       Impact factor: 7.616

9.  In vitro antibacterial activity of minocycline and effect of agar medium utilized in its susceptibility testing.

Authors:  J A Washington; P K Yu; W J Martin
Journal:  Appl Microbiol       Date:  1970-02

10.  Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin.

Authors:  L P Garrod; P M Waterworth
Journal:  J Clin Pathol       Date:  1969-09       Impact factor: 3.411
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  8 in total

1.  In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog.

Authors:  G E Zurenko; B H Yagi; J J Vavra; B B Wentworth
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191

2.  In vitro activity of temocillin against Neisseria gonorrhoeae including penicillinase-producing strains.

Authors:  A E Jephcott; S I Egglestone
Journal:  Drugs       Date:  1985       Impact factor: 9.546

3.  Cytoplasmic membrane proteins of spectinomycin-susceptible and -resistant strains of Neisseria gonorrhoeae.

Authors:  M A Miller; C S Schärli; J Mills
Journal:  J Bacteriol       Date:  1980-07       Impact factor: 3.490

4.  Penetration of spectinomycin into cerebrospinal fluid duirng experimental meningitis.

Authors:  D G Delgado; C J Brau; C K Avent
Journal:  Antimicrob Agents Chemother       Date:  1980-02       Impact factor: 5.191

5.  Activity of spectinomycin against anaerobes.

Authors:  J E Rosenblatt; A M Gerdts
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

6.  Standardization of disk diffusion and agar dilution susceptibility tests for Neisseria gonorrhoeae: interpretive criteria and quality control guidelines for ceftriaxone, penicillin, spectinomycin, and tetracycline.

Authors:  R N Jones; T L Gavan; C Thornsberry; P C Fuchs; E H Gerlach; J S Knapp; P Murray; J A Washington
Journal:  J Clin Microbiol       Date:  1989-12       Impact factor: 5.948

7.  Derivatives of 4-dihydro-4-deoxy-4(R)-amino spectinomycin and their activity against susceptible and resistant Escherichia coli strains.

Authors:  R G Werner; U L Lechner; H Goeth
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

8.  In vitro activity of spectinomycin against recent urinary tract isolates.

Authors:  R J Fass; R B Prior
Journal:  Antimicrob Agents Chemother       Date:  1977-10       Impact factor: 5.191
  8 in total

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