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Literature DB >> 4274414

Carcinoid myopathy and treatment with cyproheptadine (Periactin).

Abstract

A case of the carcinoid syndrome associated with a proximal myopathy is reported. Histology showed advanced atrophy of type II muscle fibres but no inflammation. Perinuclear acid phosphatase was increased. Electron microscopy revealed persistence of the Z-line until the muscle fibre had been severely disrupted. Similar lesions have been observed in the hereditary muscular dystrophy in mice, and also in these animals and in rats when injected with 5-hydroxytryptamine (5-HT). Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power. We suggest that the myopathy is due to circulating 5-HT or is a non-metastatic complication of the carcinoid tumour.

Entities: Chemical Disease Species

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Year: 1974 PMID： 4274414 PMCID： PMC1412931 DOI： 10.1136/gut.15.1.34

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

11 in total

1. Studies on several possible antiserotonin compounds in a patient with the functioning carcinoid syndrome.

Authors: F Q VROOM; R E BROWN; H DEMPSEY; S R HILL
Journal: Ann Intern Med Date: 1962-06 Impact factor: 25.391

2. Alterations in muscle fine structure in hereditary muscular dystrophy of mice.

Authors: M H ROSS; G D PAPPAS; P J HARMAN
Journal: Lab Invest Date: 1960 May-Jun Impact factor: 5.662

3. Increased plasma enzyme concentrations in rats with functional ischaemia of muscle provide a possible model of Duchenne muscular dystrophy.

Authors: J R Mendell; W K Engel; E C Derrer
Journal: Nature Date: 1972-10-27 Impact factor: 49.962

Carcinoid myopathy and treatment with cyproheptadine (Periactin).

1. Studies on several possible antiserotonin compounds in a patient with the functioning carcinoid syndrome.

2. Alterations in muscle fine structure in hereditary muscular dystrophy of mice.

3. Increased plasma enzyme concentrations in rats with functional ischaemia of muscle provide a possible model of Duchenne muscular dystrophy.

Review 4. The release and fate of vaso-active hormones in the circulation.

5. Carcinoid syndrome treated with streptozotocin.

6. The remote effects of cancer on the nervous system.

7. Parachlorophenylalanine treatment in carcinoid syndrome.

8. Morphologic changes in skeletal muscle induced by serotonin treatment: a light- and electron-microscope study.

9. 5-hydroxytryptamine in the circulation of the dog.

10. Myopathy, osteomalacia and hyperparathyroidism.

1. Paraneoplastic chronic intestinal pseudoobstruction as a rare complication of bronchial carcinoid.

2. Myasthenia gravis associated with a hormone producing malignant carcinoid tumour.

3. Paraneoplastic vasculitic neuropathy related to carcinoid tumor.

4. Use of somatostatin analog in management of carcinoid syndrome.

Review 5. Complications from carcinoid syndrome: review of the current evidence.