| Literature DB >> 4273909 |
C S Lee, S M Mauer, D M Brown, D E Sutherland, A F Michael, J S Najarian.
Abstract
Immunoglobulins and complement are deposited in the glomerular mesangium of rats with progressive glomerulosclerosis secondary to chemically induced diabetes mellitus. Isotransplantation of a kidney from a rat diabetic for 6 mo into a normal recipient results within 2 mo in the disappearance of IgG, IgM, and beta(1)C from the mesangium and arrest or reversal of the light microscopic glomerular lesions. Kidneys isotransplanted from normal donors into diabetic rats developed mesangial matrix thickening and deposition of IgG, IgM) and beta(1)C in the mesangium. No glomerular changes occur upon transplantation of a normal kidney into a normal rat. These findings indicate that diabetic glomerular changes in the rat are reversible and are secondary to the diabetic state rather than to the inducing agent.Entities:
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Year: 1974 PMID： 4273909 PMCID： PMC2139572 DOI： 10.1084/jem.139.4.793
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307