| Literature DB >> 427003 |
A Dresse, P Fischer, M A Gerard, K F Tempero, M A Meisinger, J A Bolognese, L Verhaest.
Abstract
1 The uricosuric effect of diflunisal was studied in eleven normal subjects. 2 Urine and serum uric acid levels were measured and used to assess the effect. 3 Diflunisal caused statistically significant decreases in serum uric acid levels and increases in uric acid clearance at 250 and 375 mg twice daily. 4 Diflunisal taken on an empty stomach caused epigastric discomfort in the high dose group which was obviated when the drug was taken with meals. 5 Diflunisal caused no abnormalities in the measured haematological, urological or biochemical parameters.Entities:
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Year: 1979 PMID： 427003 PMCID： PMC1429497 DOI： 10.1111/j.1365-2125.1979.tb00931.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335