Studies on vaccine-induced rubella arthritis. Serologic findings before and after immunization.

Rubella hemagglutination inhibition (HI) antibody responses were measured before and after immunization with HPV-77 DE/5 vaccine in 7 adult females with recurrent arthritis following rubella immunization and 24 hospital personnel studied prospectively while undergoing routine rubella immunization. The only distinctive serologic characteristic observed in all subjects developing rubella arthritis was a preimmunization HI titer of less than 1 : 8. No association was observed between the development of arthritis after immunization and prolongation of rubella HI IgM responses or elevation of rubella HI IgG responses.