| Literature DB >> 426881 |
J M Stuart, M A Cremer, S N Dixit, A H Kang, A S Townes.
Abstract
An oil emulsion of purified type II collagen from bovine articular cartilage when injected intradermally into rats induced an inflammatory polyarthritis in 4 of 12 animals. When similarly injected, collagen purified from bonve vitreous induced arthritis in 6 of 12 animals. Studies of humoral and cell-mediated immunity to both collagen preparations demonstrated complete cross-reactivity. It is concluded that vitreous collagen shares the arthritogenic property of cartilage-derived type II collagen and that collagen from the two sources is indistinguishable in arthritogenic and immunologic properties.Entities:
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Year: 1979 PMID: 426881 DOI: 10.1002/art.1780220406
Source DB: PubMed Journal: Arthritis Rheum ISSN: 0004-3591