Literature DB >> 4261561

Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor.

D G Grahame-Smith.   

Abstract

1. The hyperactivity and hyperpyrexia produced by L-tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by chlorpromazine.2. Chlorpromazine did not inhibit the increased rate of synthesis of brain 5-hydroxytryptamine (5-HT) produced by tryptophan loading.3. Hyperactivity and hyperpyrexia were also produced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) in rats. Pretreatment with a monoamine oxidase inhibitor potentiated the hyperactivity response. Pretreatment of rats with p-chlorophenylalanine did not inhibit hyperactivity produced by 5-MeODMT.4. Chlorpromazine inhibits hyperactivity caused by tryptophan or 5-MeODMT after monoamine oxidase inhibition either by competition with 5-HT or 5-MeODMT, respectively, at receptor sites or by physiological antagonism.

Entities:  

Mesh：

Substances：

Year:  1971        PMID： 4261561      PMCID： PMC1665725          DOI： 10.1111/j.1476-5381.1971.tb07222.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

1.  Behavioral effects and brain amine content in rats.

Authors:  S M HESS; W DOEPFNER
Journal:  Arch Int Pharmacodyn Ther       Date:  1961-11-01

2.  [The effect of chlorpromazine on catecholamine and 5-hydroxytryptamine metabolism in the rat brain].

Authors:  H EHRINGER; O HORNYKIEWICZ; K LECHNER
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1960

3.  Case of self-poisoning with multiple antidepressant drugs.

Authors:  A V Simmons; D Carr; E J Ross
Journal:  Lancet       Date:  1970-01-31       Impact factor: 79.321

4.  Phenelzine poisoning responding to phenothiazine.

Authors:  D D Reid; W C Kerr
Journal:  Med J Aust       Date:  1969-12-13       Impact factor: 7.738

5.  Fate and metabolism of some hallucinogenic indolealkylamines.

Authors:  U Ahlborg; B Holmstedt; J E Lindgren
Journal:  Adv Pharmacol       Date:  1968

6.  A rapid and sensitive procedure for the combined assay of noradrenaline, dopamine AND SEROTONIN IN A SINGLE BRAIN SAMPLE.

Authors:  G B Ansell; M F Beeson
Journal:  Anal Biochem       Date:  1968-05       Impact factor: 3.365

7.  Some studies of the effects of chlorpromazine, reserpine and dihydroxyphenylalanine on the concentrations of homovanillic acid, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindol-3-ylacetic acid in ventricular cerebrospinal fluid of the dog using the technique of serial sampling of the cerebrospinal fluid.

Authors:  H C Guldberg; C M Yates
Journal:  Br J Pharmacol Chemother       Date:  1968-07

8.  The biosynthesis of 5-hydroxytryptamine in brain.

Authors:  D G Grahame-Smith
Journal:  Biochem J       Date:  1967-10       Impact factor: 3.857

9.  The determination of tryptophan in plasma, liver, and urine.

Authors:  W D Denckla; H K Dewey
Journal:  J Lab Clin Med       Date:  1967-01

10.  Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan.

Authors:  D G Grahame-Smith
Journal:  J Neurochem       Date:  1971-06       Impact factor: 5.372
View more
  27 in total

1.  Hallucinogen-induced rotational behavior in rats.

Authors:  L N Fleisher; S D Glick
Journal:  Psychopharmacology (Berl)       Date:  1979-04-11       Impact factor: 4.530

2.  Characterization of receptors mediating 5-hydroxytryptamine- and catecholamine-induced platelet aggregation, assessed by the actions of alpha- and beta-blockers, butyrophenones, 5-HT antagonists and chlorpromazine.

Authors:  D J Boullin; P A Glenton
Journal:  Br J Pharmacol       Date:  1978-04       Impact factor: 8.739

3.  Proceedings: The role of brain 5-hydroxytryptamine in the hyperactivity produced in rats by lithium and monoamine oxidase inhibition.

Authors:  D G Grahame-Smith; A R Green
Journal:  Br J Pharmacol       Date:  1974-03       Impact factor: 8.739

4.  Proceedings: The role of brain dopamine in the hyperactivity syndrome produced in rats after administration of L-tryptophan and a monoamine oxidase inhibitor.

Authors:  D G Grahame-Smith; A R Green
Journal:  Br J Pharmacol       Date:  1974-03       Impact factor: 8.739

5.  A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists.

Authors:  A R Green; J E Hall; A R Rees
Journal:  Br J Pharmacol       Date:  1981-07       Impact factor: 8.739

6.  An ethopharmacological analysis of the behavioral effects of 8-OH-DPAT.

Authors:  R J Blanchard; J K Shepherd; J Armstrong; S F Tsuda; D C Blanchard
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

7.  beta-Adrenoceptor agonists enhance 5-hydroxytryptamine-mediated behavioural responses.

Authors:  P J Cowen; D G Grahame-Smith; A R Green; D J Heal
Journal:  Br J Pharmacol       Date:  1982-06       Impact factor: 8.739

8.  Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing.

Authors:  M K Mundey; A Fletcher; C A Marsden
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

9.  The role of brain 5-hydroxytryptamine in the hyperactivity produced in rats by lithium and monoamine oxidase inhibition.

Authors:  D G Grahame-Smith; A R Green
Journal:  Br J Pharmacol       Date:  1974-09       Impact factor: 8.739

10.  Elevation of brain GABA concentrations with amino-oxyacetic acid; effect on the hyperactivity syndrome produced by increased 5-hydroxytryptamine synthesis in rats.

Authors:  A R Green; A F Tordoff; M R Bloomfield
Journal:  J Neural Transm       Date:  1976       Impact factor: 3.575
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.