Literature DB >> 42610

Regulation of the induction of alkaline phosphatase in choriocarcinoma cells by sodium butyrate.

J Y Chou.   

Abstract

Alkaline phosphatase is induced in human choriocarcinoma cells by short-chain fatty acids, especially sodium butyrate. This fatty acid increases the phosphatase activity immediately and in a nearly linear fashion. Only phosphatase with an alkaline pH optimum is induced. Both the induced alkaline phosphatase and the basal enzyme are precipitated by antiserum against term-placental alkaline phosphatase, but the choriocarcinoma phosphatase is less stable to heating than is the term-placental enzyme. The induction of alkaline phosphatase activity requires cellular synthesis of protein, RNA and DNA. The regulation of induction probably occurs at the transcriptional level.

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Year:  1979        PMID： 42610     DOI： 10.1007/bf02618305

Source DB:  PubMed          Journal:  In Vitro        ISSN： 0073-5655


  26 in total

1.  Induction of alkaline phosphatase in choriocarcinoma cells by 1-beta-D-arabinofuranosyl-cytosine, mitomycin C, phleomycin, and cyclic nucleotides.

Authors:  J Y Chou; J C Robinson
Journal:  J Cell Physiol       Date:  1977-08       Impact factor: 6.384

2.  Effects of sodium butyrate on synthesis of human chorionic gonadotrophin in trophoblastic and non-trophoblastic tumours.

Authors:  J Y Chou; J C Robinson; S S Wang
Journal:  Nature       Date:  1977-08-11       Impact factor: 49.962

3.  Morphological and biochemical differentiation in HeLa cells. Effects of cycloheximide on butyrate-induced process formation and ganglioside metabolism.

Authors:  R C Henneberry; P H Fishman
Journal:  Exp Cell Res       Date:  1976-11       Impact factor: 3.905

4.  Increased alkaline phosphatase activity in HeLa cells mediated by aliphatic monocarboxylates and inhibitors of DNA synthesis.

Authors:  S I Deutsch; N K Ghosh; R P Cox
Journal:  Biochim Biophys Acta       Date:  1977-10-25

5.  Effect of sodium butyrate on mammalian cells in culture: a review.

Authors:  K N Prasad; P K Sinha
Journal:  In Vitro       Date:  1976-02

6.  Isolation of hormone-producing clonal lines of human choriocarcinoma.

Authors:  P O Kohler; W E Bridson
Journal:  J Clin Endocrinol Metab       Date:  1971-05       Impact factor: 5.958

7.  Human alkaline phosphatase. Immunochemical identification of organ-specific isoenzymes.

Authors:  H H Sussman; P A Small; E Cotlove
Journal:  J Biol Chem       Date:  1968-01-10       Impact factor: 5.157

8.  Butyric acid suppression of the in vitro neoplastic state of Syrian hamster cells.

Authors:  J Leavitt; J C Barrett; B D Crawford; P O Ts'o
Journal:  Nature       Date:  1978-01-19       Impact factor: 49.962

9.  Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences.

Authors:  G Vidali; L C Boffa; E M Bradbury; V G Allfrey
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

10.  Effect of n-butyrate on DNA synthesis in chick fibroblasts and HeLa cells.

Authors:  H K Hagopian; M G Riggs; L A Swartz; V M Ingram
Journal:  Cell       Date:  1977-11       Impact factor: 41.582
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  1 in total

1.  Modulation of alkaline phosphatase activity in alveolar type II like cells.

Authors:  M Kalina; D Levi; S Riklis
Journal:  Histochemistry       Date:  1990
  1 in total

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