Literature DB >> 4252539

Mucopolysaccharide and protein--polysaccharide of a transplantable rat chondrosarcoma.

H U Choi, K Meyer, R Swarm.   

Abstract

Two mucopolysaccharides, chondroitin 4-sulfate (97.8%) and hyaluronic acid (1.2%), were isolated after exhaustive proteolysis of a transplantable chondrosarcoma of the rat. The chondroitin 4-sulfate was fractionated into three fractions of varying degrees of sulfation and chain length. Keratan sulfate and chondroitin 6-sulfate were absent. Extraction of the fresh tumor gave two protein-polysaccharides of similar carbohydrate composition, one soluble in 0.5 M NaCl, the other insoluble. The latter was solubilized in 4 M guanidine.HCl. A dialyzable fraction from the 4 M guanidine solution may be responsible for the insolubility. Both protein-polysaccharides were antigenic and cross-reacted with similar fractions of bovine and human cartilage.

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Year:  1971        PMID： 4252539      PMCID： PMC389070          DOI： 10.1073/pnas.68.5.877

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

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Authors:  D KAPLAN; K MEYER
Journal:  Nature       Date:  1959-05-02       Impact factor: 49.962

2.  The acid mucopolysaccharides of connective tissue.

Authors:  E DAVIDSON; P HOFFMAN; A LINKER; K MEYER
Journal:  Biochim Biophys Acta       Date:  1956-09

3.  Application of cetylpyridinium-complex elution methods to analysis of glycosaminoglycans of tendon.

Authors:  R W Dorner; C A Antonopoulos; S Gardell
Journal:  Biochim Biophys Acta       Date:  1968-06-24

4.  Macromolecular models of proteinpolysaccharides from bovine nasal cartilage based on electron microscopic studies.

Authors:  L Rosenberg; W Hellmann; A K Kleinschmidt
Journal:  J Biol Chem       Date:  1970-08-25       Impact factor: 5.157

5.  Purification and properties of bacterial chondroitinases and chondrosulfatases.

Authors:  T Yamagata; H Saito; O Habuchi; S Suzuki
Journal:  J Biol Chem       Date:  1968-04-10       Impact factor: 5.157

6.  Biosynthesis of chondroitin sulfate. I. Galactosyl transfer in the formation of the carbohydrate-protein linkage region.

Authors:  T Helting; L Rodén
Journal:  J Biol Chem       Date:  1969-05-25       Impact factor: 5.157

7.  Proteinpolysaccharide complex from bovine nasal cartilage. The function of glycoprotein in the formation of aggregates.

Authors:  V C Hascall; S W Sajdera
Journal:  J Biol Chem       Date:  1969-05-10       Impact factor: 5.157

8.  Serine and threonine glycosidic linkages in bovine submaxillary mucin.

Authors:  K Tanaka; M Bertolini; W Pigman
Journal:  Biochem Biophys Res Commun       Date:  1964-07-27       Impact factor: 3.575

9.  Protein-polyaccharide of chicken cartilage and chondrocyte cell cultures.

Authors:  H J Shulman; K Meyer
Journal:  Biochem J       Date:  1970-12       Impact factor: 3.857
  9 in total
  21 in total

1.  Studies of a monoclonal antibody to skeletal keratan sulphate. Importance of antibody valency.

Authors:  A R Poole; C Webber; A Reiner; P J Roughley
Journal:  Biochem J       Date:  1989-06-15       Impact factor: 3.857

2.  Isoform-specific heparan sulfate binding within the amino-terminal noncollagenous domain of collagen alpha1(XI).

Authors:  Lisa R Warner; Raquel J Brown; Sorcha M C Yingst; Julia Thom Oxford
Journal:  J Biol Chem       Date:  2006-10-24       Impact factor: 5.157

3.  Intracellular domain fragment of CD44 alters CD44 function in chondrocytes.

Authors:  Liliana Mellor; Cheryl B Knudson; Daisuke Hida; Emily B Askew; Warren Knudson
Journal:  J Biol Chem       Date:  2013-07-24       Impact factor: 5.157

4.  Simvastatin promotes restoration of chondrocyte morphology and phenotype.

Authors:  Kenya Terabe; Nobunori Takahashi; Michelle Cobb; Emily B Askew; Cheryl B Knudson; Warren Knudson
Journal:  Arch Biochem Biophys       Date:  2019-02-15       Impact factor: 4.013

5.  Cytogenetics of swarm rat chondrosarcoma.

Authors:  Jeff W Stevens; Shivanand R Patil; Diane K Jordan; James H Kimura; Jose A Morcuende
Journal:  Iowa Orthop J       Date:  2005

6.  SP1-binding elements, within the common metaxin-thrombospondin 3 intergenic region, participate in the regulation of the metaxin gene.

Authors:  M Collins; P Bornstein
Journal:  Nucleic Acids Res       Date:  1996-10-01       Impact factor: 16.971

7.  Heterogeneity in growth properties of the rat Swarm chondrosarcoma.

Authors:  Jeff W Stevens
Journal:  Iowa Orthop J       Date:  2004

8.  Immunochemistry of cartilage proteoglycan. Immunodiffusion and gel-electrophoretic studies.

Authors:  H Keiser; H J Shulman; J I Sandson
Journal:  Biochem J       Date:  1972-01       Impact factor: 3.857

9.  Control of chondrogenic expression in mesodermal cells of embryonic chick limb.

Authors:  A I Caplan; A C Stoolmiller
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205

10.  Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in increased tumorigenicity.

Authors:  Christopher A Hamm; Hehuang Xie; Fabricio F Costa; Elio F Vanin; Elisabeth A Seftor; Simone T Sredni; Jared Bischof; Deli Wang; Maria F Bonaldo; Mary J C Hendrix; Marcelo B Soares
Journal:  PLoS One       Date:  2009-12-17       Impact factor: 3.240
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