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Literature DB >> 4244871

Reduction in incidence of ampicillin rash by purification of ampicillin.

Abstract

Purification of ampicillin (Penbritin) with respect to protein impurities has been found significantly to reduce the incidence of rashes in treated patients. This may be related to findings in animals that injections of the isolated protein impurity can induce the formation of circulating IgG antibodies and skin-sensitizing antibodies.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1970 PMID： 4244871 PMCID： PMC1699418 DOI： 10.1136/bmj.1.5694.469

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

9 in total

1. THE SPECIFICITY OF HEMAGGLUTINATION REACTIONS IN HUMAN AND EXPERIMENTAL PENICILLIN HYPERSENSITIVITY.

Authors: J A THIEL; S MITCHELL; C W PARKER
Journal: J Allergy Date: 1964 Sep-Oct

2. COMPARISON OF AMPICILLIN AND CHLORAMPHENICOL IN TREATMENT OF PARATYPHOID FEVER.

Authors: R A SLEET; G SANGSTER; J M MURDOCH
Journal: Br Med J Date: 1964-01-18

3. Cutaneous sensitivity to purified benzylpenicillin.

Authors: E T Knudsen; O P Robinson; E A Croydon; E C Tees
Journal: Lancet Date: 1967-06-03 Impact factor: 79.321

4. A penicilloylated protein impurity as a source of allergy to benzylpenicillin and 6-aminopenicillanic acid.

Authors: F R Batchelor; J M Dewdney; J G Feinberg; R D Weston
Journal: Lancet Date: 1967-06-03 Impact factor: 79.321

5. Allergenic residues in penicillins.

Authors: G T Stewart
Journal: Lancet Date: 1967-06-03 Impact factor: 79.321

6. Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis.

Authors: H Pullen; N Wright; J M Murdoch
Journal: Lancet Date: 1967-12-02 Impact factor: 79.321

7. Drug rash with ampicillin and other penicillins.

Authors: S Shapiro; V Siskind; D Slone; G P Lewis; H Jick
Journal: Lancet Date: 1969-11-08 Impact factor: 79.321

8. Treatment of common genitourinary tract infections with oral ampicillin.

Authors: G Cuellar; R Puente
Journal: Curr Ther Res Clin Exp Date: 1967-10

9. Ampicillin and the fifth-day rash.

Authors: J Stevenson; B Mandal
Journal: Br Med J Date: 1966-05-28

9 in total

6 in total

Reduction in incidence of ampicillin rash by purification of ampicillin.

1. THE SPECIFICITY OF HEMAGGLUTINATION REACTIONS IN HUMAN AND EXPERIMENTAL PENICILLIN HYPERSENSITIVITY.

2. COMPARISON OF AMPICILLIN AND CHLORAMPHENICOL IN TREATMENT OF PARATYPHOID FEVER.

3. Cutaneous sensitivity to purified benzylpenicillin.

4. A penicilloylated protein impurity as a source of allergy to benzylpenicillin and 6-aminopenicillanic acid.

5. Allergenic residues in penicillins.

6. Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis.

7. Drug rash with ampicillin and other penicillins.

8. Treatment of common genitourinary tract infections with oral ampicillin.

9. Ampicillin and the fifth-day rash.

1. Editorial: Ampicillin rashes.

2. Reduction in incidence of rash using polymer-free ampicillin.

3. IgM and IgG antibody levels to ampicillin in patients with infectious mononucleosis.

4. The formation of antigenic polymers in aqueous solutions of -lactam antibiotics.

5. Ampicillin rash.

6. Prospective study of ampicillin rash. Report of a collaborative study group.