The effects of hyaluronidase on the immobilization of goats by intramuscular succinylcholine chloride.

In this report, the effects of hyaluronidase on the absorption of intramuscular succinylcholine chloride in goats are discussed. Twenty-five mature, mixed-strain dairy goats were immobilized with 0.33 mg/kg of the drug. An additional 25 goats were given corresponding doses to which hyaluronidase (150 NF units per vial of succinylcholine) had been added. The latent period (the time from injection to collapse) is reduced by 25% in goats given the drug-enzyme mixture. It is concluded that hyaluronidase increases the rate of absorption of succinylcholine chloride. However, it produces no significant difference in the duration of paralysis.