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Literature DB >> 4235174

Histochemical investigation of acid mucosubstances in secondary amyloidosis.

Abstract

Sections of liver and spleen from six cases of secondary amyloidosis have been examined, by various improved histochemical methods, for acidic mucosubstances. The results indicate a complex in amyloid deposits of protein and sulphated mucopolysaccharides in which the principal substance is heparan sulphate with traces of chondroitin sulphates. Deposits also contain sialic acid. The results are compared with chemical analyses of the same tissues and isolated fibrils which confirm the presence of heparan sulphate, chondroitin sulphates, and a sialic acid containing protein.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1968 PMID： 4235174 PMCID： PMC473866 DOI： 10.1136/jcp.21.5.578

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

14 in total

4. Isolation and characterization of the integral glycosaminoglycan constituents of human amyloid A and monoclonal light-chain amyloid fibrils.

Authors: S R Nelson; M Lyon; J T Gallagher; E A Johnson; M B Pepys
Journal: Biochem J Date: 1991-04-01 Impact factor: 3.857

4 in total

Histochemical investigation of acid mucosubstances in secondary amyloidosis.

1. A study of the histochemical and staining characteristics of amyloid.

2. Acid mucopolysaccharide from a spleen of primary amyloidosis.

3. Electron microscopic observations on a fibrous component in amyloid of diverse origins.

4. Some observations on the histochemical reactions of amyloid.

5. The acid mucopolysaccharides of connective tissue.

6. Association of acid mucopolysaccharides with isolated amyloid fibrils.

7. The specificity of the staining of amyloid deposits with thioflavine T.

8. Investigation of glycoprotein material associated with hepatic amyloid.

9. Mucopolysaccharides of whole human spleens in generalized amyloidosis.

10. Amyloid. 3. A protein related to the subunit structure of human amyloid fibrils.

1. Pustular psoriasis and amyloidosis.

2. The effect of beta aminoproprionitrile (BAPN) on experimental amyloidosis.

Review 3. The role of novel chitin-like polysaccharides in Alzheimer disease.

4. Isolation and characterization of the integral glycosaminoglycan constituents of human amyloid A and monoclonal light-chain amyloid fibrils.