Literature DB >> 423216

Preparation and antidiabetic activity of some sulfonylurea derivatives of 3,5-disubstituted pyrazoles.

R Soliman.   

Abstract

Four series of p-[3,5-dimethyl- (and 5-methyl-3-carboxy-) pyrazole-1]benzenesulfonylureas, thioureas, 2-thiohydantions, and 5,6-dihydro-4(3H)-oxo-2(1H)-pyrimidinethiones were prepared for evaluation as hypoglycemic agents. Biological testing of these compounds showed that some possessed antidiabetic activity.

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Year:  1979        PMID: 423216     DOI: 10.1021/jm00189a022

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  5 in total

1.  Microwave-enhanced liquid-phase synthesis of thiohydantoins and thioxotetrahydropyrimidinones.

Authors:  Wen-Ben Yeh; Mei-Jung Lin; Ming-Juan Lee; Chung-Ming Sun
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

2.  Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus.

Authors:  Diana Cordero; Christopher R Fullenkamp; Rachel R Pelly; Katie M Reed; Lindy M Caffo; Ashley N Zahrt; Micaleah Newman; Sarah Komanapalli; Evan M Niemeier; Derron L Bishop; Heather A Bruns; Mark K Haynes; Larry A Sklar; Robert E Sammelson; Susan A McDowell
Journal:  Curr Pharm Biotechnol       Date:  2014       Impact factor: 2.837

3.  Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines.

Authors:  Jinhong Park; Poonam Khloya; Yohan Seo; Satish Kumar; Ho K Lee; Dong-Kyu Jeon; Sungwoo Jo; Pawan K Sharma; Wan Namkung
Journal:  PLoS One       Date:  2016-02-10       Impact factor: 3.240

4.  Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene.

Authors:  Maria Ivanova; Julien Legros; Thomas Poisson; Philippe Jubault
Journal:  J Flow Chem       Date:  2021-10-05       Impact factor: 3.264

5.  Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity.

Authors:  Mona F Said; Riham F George; Andrea Petreni; Claudiu T Supuran; Nada M Mohamed
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

  5 in total

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