Literature DB >> 423202

Bicyclic pyrazolines, potential central nervous system depressants and antiinflammatory agents.

J Krapcho, C F Turk.   

Abstract

The synthesis and CNS activity of a series of 34 substituted bicyclic pyrazolines are described. Ten of these compounds were also screened for antiinflammatory activity. One of the compounds (15) exhibited significant antiinflammatory activity in the carrageenan-induced edema test.

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Year:  1979        PMID: 423202     DOI: 10.1021/jm00188a018

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  3 in total

1.  Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of Opioid Receptor affinity.

Authors:  Gianfranco Fontana; Giuseppe Savona; Benjamín Rodríguez; Christina M Dersch; Richard B Rothman; Thomas E Prisinzano
Journal:  Tetrahedron       Date:  2008-12-20       Impact factor: 2.457

2.  (3E,5E)-1-Benzyl-3,5-bis-(2-fluoro-benzyl-idene)piperidin-4-one.

Authors:  R S Rathore; N S Karthikeyan; K Sathiyanarayanan; P G Aravindan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-07

3.  (3E,5E)-1-Benzyl-3,5-dibenzyl-idenepiperidin-4-one.

Authors:  N S Karthikeyan; K Sathiyanarayanan; P G Aravindan; R S Rathore
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-17
  3 in total

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