Literature DB >> 423174

11-Oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid, an orally active antiallergy agent.

C F Schwender, B R Sunday, D J Herzig.   

Abstract

A new series of 11-oxo-11H-pyrido[2,1-b]quinazolinecarboxylic acids and related analogues has been synthesized and evaluated as potential antiallergy agents. In the rat PCA test, 11-oxo-11H-pyrido[2,1--b]quinazoline-8-carboxylic acid is orally active and more potent than cromolyn sodium or doxantrazole intravenously.

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Year:  1979        PMID： 423174     DOI： 10.1021/jm00187a026

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  2 in total

1.  Preparation, characterization and stability of cross linked nitrilase aggregates (nitrilase-CLEAs) for hydroxylation of 2-chloroisonicotinonitrile to 2-chloroisonicotinic acid.

Authors:  Amol Gulab Khatik; Arvind Kumar Jain; Abhijeet Bhimrao Muley
Journal:  Bioprocess Biosyst Eng       Date:  2022-08-13       Impact factor: 3.434

2.  Ru(II)/Ir(III)-Catalyzed C-H Bond Activation/Annulation of Cyclic Amides with 1,3-Diketone-2-diazo Compounds: Facile Access to 8H-Isoquinolino[1,2-b]quinazolin-8-ones and Phthalazino[2,3-a]cinnoline-8,13-diones.

Authors:  Panyuan Cai; Enshen Zhang; Yinsong Wu; Taibei Fang; Qianqian Li; Chen Yang; Jian Wang; Yongjia Shang
Journal:  ACS Omega       Date:  2018-11-01
  2 in total

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