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Literature DB >> 4231047

3-acetylpyridine: effects in vitro related to teratogenic activity in chicken embryos.

Abstract

Production of skeletal muscle hypoplasia by 3-acetylpyridine and its complete reversal by nicotinamide in developing chicken embryos have been confirmed. Cultures of developing embryonic chicken muscle show degenerative effects produced by 3-acetylpyridine; these effects are reversed by nicotinamide. Cartilage production in cultured chondrogenic cells is potentiated by 3-acetylpyridine; this potentiation is completely reversed by nicotinamide. It is suggested that nicotinamide-or pyridine-nucleotide-dependent reactions influence normal differentiation of limb mesoderm cells by inhibiting chondrogenic-cell and potentiating muscle-cell expression or proliferation.

Entities: Chemical Disease Species

Mesh：

Substances：
Pyridines
Niacinamide

Year: 1968 PMID： 4231047 DOI： 10.1126/science.160.3831.1009

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

11 in total

1. Interrelationship between poly (ADP-Rib) synthesis, intracellular NAD levels, and muscle or cartilage differentiation from mesodermal cells of embryonic chick limb.

Authors: A I Caplan; M J Rosenberg
Journal: Proc Natl Acad Sci U S A Date: 1975-05 Impact factor: 11.205

2. Development of parathyroid hormone- and calcitonin-activated adenylate cyclases in embryonic chicken limb and in cultured cells from embryonic chicken limb.

Authors: J E Zull; S Krug; D Abel; A I Caplan
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

10. Transformation of mammalian fibroblasts and macrophages in vitro by a murine retrovirus encoding an avian v-myc oncogene.

Authors: B Vennström; P Kahn; B Adkins; P Enrietto; M J Hayman; T Graf; P Luciw
Journal: EMBO J Date: 1984-12-20 Impact factor: 11.598

3-acetylpyridine: effects in vitro related to teratogenic activity in chicken embryos.

1. Interrelationship between poly (ADP-Rib) synthesis, intracellular NAD levels, and muscle or cartilage differentiation from mesodermal cells of embryonic chick limb.

2. Development of parathyroid hormone- and calcitonin-activated adenylate cyclases in embryonic chicken limb and in cultured cells from embryonic chicken limb.

3. Translation and characterization of messenger RNAs in differentiating chicken cartilage.

4. Actin and myosinlike structure induced in the growth cartilage by acute ischemia.

5. Is homarine a morphogen in the marine hydroid Hydractinia?

6. Control of chondrogenic expression in mesodermal cells of embryonic chick limb.

7. Development of the cyclic AMP response to parathyroid hormone and prostaglandin E2 in the embryonic chick limb.

8. Mesenchymal Stem Cells: The Past, the Present, the Future.

9. Mesenchymal Stem Cells: Time to Change the Name!

10. Transformation of mammalian fibroblasts and macrophages in vitro by a murine retrovirus encoding an avian v-myc oncogene.