An apparent relationship between locoism and lathyrism.

An apparent relationship between locoism and lathyrism was investigated. Similarities reported in the literature in botanical relationship, signs produced in affected animals, and chemical characteristics were noted. It was demonstrated that the known lathyrogens, aminoacetonitrile and alpha, gamma-diaminobutyric acid, as well as an extract from the loco plant (expected to contain lathyrogens if present in the plant) produced many of the abortive, teratogenic and neurologic effects and signs evident in animals in true locoism. Preliminary assay of extracts from the plant suggested the presence of lathyrogens in the loco plant.