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Literature DB >> 4226177

Citrate and the regulation of adipose-tissue phosphofructokinase.

Abstract

1. Methods are described for the extraction, partial purification and assay of phosphofructokinase in rat epididymal adipose tissue. 2. The enzyme was inhibited by ATP at concentrations above 20mum and by citrate; the enzyme was activated by ADP, AMP, 3',5'-(cyclic)-AMP, phosphate and sulphate. 3. The enzyme lost activity on incubation at 25 degrees or during chromatography on DEAE-cellulose unless fluoride at a concentration of 4mm was present. 4. The significance of these results in relation to the role of glycolysis and citrate in lipogenesis is discussed.

Entities: Chemical Species

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Year: 1966 PMID： 4226177 PMCID： PMC1265151 DOI： 10.1042/bj1000420

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. STUDIES ON THE METABOLISM OF ADIPOSE TISSUE. XV. AN EVALUATION OF THE MAJOR PATHWAYS OF GLUCOSE CATABOLISM AS INFLUENCED BY INSULIN AND EPINEPHRINE.

Authors: J P FLATT; E G BALL
Journal: J Biol Chem Date: 1964-03 Impact factor: 5.157

2. CITRATE AS AN INTERMEDIARY IN THE INHIBITION OF PHOSPHOFRUCTOKINASE IN RAT HEART MUSCLE BY FATTY ACIDS, KETONE BODIES, PYRUVATE, DIABETES, AND STARVATION.

Authors: P B GARLAND; P J RANDLE; E A NEWSHOLME
Journal: Nature Date: 1963-10-12 Impact factor: 49.962

3. STUDIES ON HEART PHOSPHOFRUCTOKINASE. ACTIVE AND INACTIVE FORMS OF THE ENZYME.

Authors: T E MANSOUR
Journal: J Biol Chem Date: 1965-05 Impact factor: 5.157

4. [ON THE BIOSYNTHESIS OF FATTY ACIDS. V. ACETYL-COA CARBOXYLASE FROM RAT LIVER AND ITS ACTIVATION BY CITRIC ACID].

Authors: M MATSUHASHI; S MATSUHASHI; F LYNEN
Journal: Biochem Z Date: 1964-08-11

5. Citrate cleavage in adipose tissue.

Authors: M S Kornacker; E G Ball
Journal: Proc Natl Acad Sci U S A Date: 1965-09 Impact factor: 11.205

6. The role of phosphofructokinase in metabolic regulation.

Authors: J V Passonneau; O H Lowry
Journal: Adv Enzyme Regul Date: 1964

7. Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in perfused rat heart.

Authors: E A Newsholme; P J Randle
Journal: Biochem J Date: 1964-12 Impact factor: 3.857

8. Two interconvertible forms of yeast phosphofructokinase with different sensitivity to endproduct inhibition.

Authors: E Viñuela; M L Salas; M Salas; A Sols
Journal: Biochem Biophys Res Commun Date: 1964-03-26 Impact factor: 3.575

9. Concerning the form in which acetyl units produced in mitochondria are transferred to the site of de novo fatty acid synthesis in the cell.

Authors: J Bartley; S Abraham; I L Chaikoff
Journal: Biochem Biophys Res Commun Date: 1965-06-09 Impact factor: 3.575

10. Adenosine 3',5'-monophosphate in biological materials. II. The measurement of adenosine 3',5'-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine.

Authors: R W Butcher; R J Ho; H C Meng; E W Sutherland
Journal: J Biol Chem Date: 1965-11 Impact factor: 5.157

22 in total

1. Adipose-tissue phosphofructokinase. Rapid purification and regulation by phosphorylation in vitro.

Authors: E M Sale; R M Denton
Journal: Biochem J Date: 1985-12-15 Impact factor: 3.857

2. The second messenger concept and lipid metabolism.

Authors: R W Butcher
Journal: Naunyn Schmiedebergs Arch Pharmakol Date: 1971

3. [The impairment of glycogen metabolism in adipose tissue by 6-aminonicotinamide as influenced by the inhibition of phosphofructokinase].

Authors: N Ofori-Nkansah; F von Bruchhausen
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1972 Impact factor: 3.000

Review 4. [Biochemical bases of disturbed interactions between carbohydrate and fat metabolism in diabetes mellitus].

Authors: B Schulze; H Kaffarnik
Journal: Klin Wochenschr Date: 1970-10-01

5. Study of the metabolism in vitro of glucose in the rat epididymal fat tissue. Stimulating effect of palmitic acid.

Authors: N Zaragoza; J P Felber
Journal: Diabetologia Date: 1969-10 Impact factor: 10.122

6. Glucose metabolism in the superovulated rat ovary in vitro. Effects of luteinizing hormone and the role of glucose metabolism in steroidogenesis.

Authors: A P Flint; R M Denton
Journal: Biochem J Date: 1969-04 Impact factor: 3.857

7. The effect of dietary and hormonal conditions on the activities of glycolytic enzymes in rat epididymal adipose tissue.

Authors: E D Saggerson; A L Greenbaum
Journal: Biochem J Date: 1969-11 Impact factor: 3.857

8. The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. Effects of altered dietary and hormonal conditions.

Authors: E D Saggerson; A L Greenbaum
Journal: Biochem J Date: 1970-09 Impact factor: 3.857

9. Mechanisms regulating adipose-tissue pyruvate dehydrogenase.

Authors: B R Martin; R M Denton; H T Pask; P J Randle
Journal: Biochem J Date: 1972-09 Impact factor: 3.857

10. The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue.

Authors: E D Saggerson; A L Greenbaum
Journal: Biochem J Date: 1970-09 Impact factor: 3.857