Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Common antigens among systemic disease fungi analyzed by two-dimensional immunoelectrophoresis.

Literature DB >> 422249

Common antigens among systemic disease fungi analyzed by two-dimensional immunoelectrophoresis.

M Huppert, J P Adler, E H Rice, S H Sun.

Abstract

The interpretation of immunological results in systemic mycoses has been complicated by cross-reactions among specimens from patients with blastomycosis, coccidioidomycosis, and histoplasmosis. The fungal preparations used in these tests evidently contained one or more antigens in common. Two-dimensional immunoelectrophoresis techniques were used to determine the number of antigens contained in several soluble extracts from Blastomyces dermatitidis and Histoplasma capsulatum that were common with those demonstrable in a coccidiodin-anticoccidioidin reference system. A total of 12 and 10 common antigens were found in preparations from B. dermatitidis and H. capsulatum, respectively. In addition, the crude preparations from each species of fungus exhibited some qualitative and quantitative differences in composition of antigens. Use of two-dimensional immunoelectrophoresis for standardization of fungus extracts, for monitoring separation of species-specific antigens, and for testing humoral antibody response should add further refinement to correlations with clinical disease.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1979 PMID： 422249 PMCID： PMC414190 DOI： 10.1128/iai.23.2.479-485.1979

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

14 in total

1. Disseminated histoplasmosis followed by disseminated coccidioidomycosis.

Authors: P Kaplan; J R Graybill; D Thor
Journal: Chest Date: 1977-08 Impact factor: 9.410

2. Scientific Assembly statement. The use of skin tests and serologic tests in histoplasmosis, coccidioidomycosis, and blastomycosis, 1973.

Authors: E W Chick; G L Baum; M L Furcolow; M Huppert; L Kaufman; R Pappagianis
Journal: Am Rev Respir Dis Date: 1973-07

Review 3. The current status of serologic, immunologic and skin tests in the diagnosis of pulmonary mycoses. Report of the Committee on Fungus Diseases and Subcommittee on Criteria for Clinical Diagnosis--American College of Chest Physicians.

Authors:
Journal: Chest Date: 1973-02 Impact factor: 9.410

Common antigens among systemic disease fungi analyzed by two-dimensional immunoelectrophoresis.

1. Disseminated histoplasmosis followed by disseminated coccidioidomycosis.

2. Scientific Assembly statement. The use of skin tests and serologic tests in histoplasmosis, coccidioidomycosis, and blastomycosis, 1973.

Review 3. The current status of serologic, immunologic and skin tests in the diagnosis of pulmonary mycoses. Report of the Committee on Fungus Diseases and Subcommittee on Criteria for Clinical Diagnosis--American College of Chest Physicians.

4. Dermal sensitivity to Coccidioides immitis. A comparison of responses elicited in man by spherulin and coccidioidin.

5. Spherule coccidioidin in delayed dermal sensitivity reactions of experimental animals.

6. Specific immunodiffusion test for blastomycosis.

7. Antigenic analysis of coccidioidin and spherulin determined by two-dimensional immunoelectrophoresis.

8. Patterns of human antibody reactions in coccidioidomycosis.

9. Delayed-type hypersensitivity responses to a cell wall fraction of the mycelial phase of Coccidioides immitis.

10. Cell wall composition of two strains of Blastomyces dermatitidis exhibiting differences in virulence for mice.

1. Production and characterization of a monoclonal antibody to the complement fixation antigen of Coccidioides immitis.

2. Production of a murine monoclonal antibody that recognizes an epitope specific to Coccidioides immitis antigen 2.

3. An immunoreactive, water-soluble conidial wall fraction of Coccidioides immitis.

4. Revision and return of a coccidioidal skin test reagent.

5. DIAGNOSIS OF HISTOPLASMOSIS.

6. Production and characterization of murine monoclonal antibodies to Histoplasma capsulatum yeast cell antigens.

7. Evaluation of cross-reactions in Histoplasma capsulatum serologic tests.

8. Antigen complex of Coccidioides immitis which elicits a precipitin antibody response in patients.

Review 9. Coccidioidomycosis: host response and vaccine development.

10. Molecular and biochemical characterization of a Coccidioides immitis-specific antigen.