Literature DB >> 4218957

Biological, proton-magnetic-resonance- and ultraviolet-spectroscopic evidence for a molecular complex of actinomycin D and 10,11-dihydro-3H-naphth (1,2-g)indazol-7-ol.

R W Chesnut, N N Durham, E Mawdsley, G X Thyvelikakath, K D Berlin, B M Fung.   

Abstract

A proton-magnetic-resonance study of the complex formed between actinomycin D and 10,11-dihydro-3H-naphth[1,2-g]indazol-7-ol strongly suggests that the indazole lies above the phenoxazine ring of actinomycin D. The complex can be destroyed by addition of dimethyl sulphoxide or dimethylformamide. The actinomycin D-indazole complex inhibits growth of Pseudomonas fluorescens and raises the thermal denaturation response of DNA. These data support the hypothesis that a molecular complex is formed which readily inhibits cell growth and interacts with DNA.

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Year:  1974        PMID： 4218957      PMCID： PMC1168452          DOI： 10.1042/bj1430789

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  [On the behavior of actinomycins in aqueous solutions].

Authors:  W Müller; I Emme
Journal:  Z Naturforsch B       Date:  1965-09       Impact factor: 1.047

2.  Studies concerning the behavior of actinomycin in solution.

Authors:  D M Crothers; S L Sabol; D I Ratner; W Müller
Journal:  Biochemistry       Date:  1968-05       Impact factor: 3.162

3.  Susceptibility of E. coli K-12 to actinomycin D after infection with phage M13.

Authors:  A Roy; S Mitra
Journal:  Nature       Date:  1970-10-24       Impact factor: 49.962

4.  Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin.

Authors:  H Riehm; J L Biedler
Journal:  Cancer Res       Date:  1972-06       Impact factor: 12.701

5.  Molecular specificity associated with alleviation of actinomycin D inhibition of protein synthesis.

Authors:  N N Durham; D V Ferguson
Journal:  Biochem J       Date:  1971-06       Impact factor: 3.857

6.  Synthesis of protocatechuate oxygenase by Pseudomonas fluorescens in the presence of actinomycin D.

Authors:  N N Durham; K C Keudell
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1969

7.  Nuclear magnetic resonance spectral studies on actinomycin D. Preliminary observations on the effect of complex formation with 5'-deoxyguanylic acid.

Authors:  B H Arison; K Hoogsteen
Journal:  Biochemistry       Date:  1970-09-29       Impact factor: 3.162

8.  [Interaction between pigments and nucleic acids. 6. Study of the interaction of actinomycin with DNA by optical rotatory dispersion].

Authors:  Y Courtois; W Guschlbauer; P Fromageot
Journal:  Eur J Biochem       Date:  1968-10-17

9.  Release of lipopolysaccharide by EDTA treatment of E. coli.

Authors:  L Leive
Journal:  Biochem Biophys Res Commun       Date:  1965-11-22       Impact factor: 3.575

10.  Mechanism of biological action of a new benzindazole compound.

Authors:  R W Chesnut; D F Haslam; N N Durham; K D Berlin
Journal:  Can J Biochem       Date:  1972-05
  10 in total

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