Literature DB >> 421856

Lymphopenia and lymphocyte transformation in alcoholics.

G P Young, M B Van der Weyden, I S Rose, F J Dudley.   

Abstract

The basis of peripheral blood lymphopenia observed in patients with chronic alcoholism and liver disease was investigated by examining the effect of sera of these patients on in vitro transformation of normal human peripheral blood lymphocytes. A positive correlation was demonstrated between the serum inhibition of phytohaemagglutinin- and pokeweed mitogen-induced transformation and the degree of lymphopenia. Thus serum factors may contribute to the observed lymphopenia by inhibiting lymphocyte production in vivo.

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Year:  1979        PMID： 421856     DOI： 10.1007/bf01920656

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  3 in total

1.  Reduction in circulating T lymphocytes in alcoholic liver disease.

Authors:  I M Bernstein; K H Webster; R C Williams; R G Strickland
Journal:  Lancet       Date:  1974-08-31       Impact factor: 79.321

2.  Depression of lymphocyte reactivity to phytohemagglutinin by serum from patients with liver disease.

Authors:  W M Newberry; J W Shorey; J P Sanford; B Combes
Journal:  Cell Immunol       Date:  1973-01       Impact factor: 4.868

3.  Inhibition of PHA-stimulated lymphocyte transformation by plasma from patients with advanced alcoholic cirrhosis.

Authors:  C C Hsu; C M Leevy
Journal:  Clin Exp Immunol       Date:  1971-05       Impact factor: 4.330
  3 in total
  7 in total

1.  Ethanol and vitamin D receptor in T cell apoptosis.

Authors:  Shabina Rehman; Nirupama Chandel; Divya Salhan; Partab Rai; Bipin Sharma; Tejinder Singh; Mohammad Husain; Ashwani Malhotra; Pravin C Singhal
Journal:  J Neuroimmune Pharmacol       Date:  2012-10-06       Impact factor: 4.147

2.  Suppressive effect of alcoholic liver disease sera on lymphocyte transformation.

Authors:  G P Young; F J Dudley; M B Van Der Weyden
Journal:  Gut       Date:  1979-10       Impact factor: 23.059

3.  Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells.

Authors:  Smita S Ghare; Swati Joshi-Barve; Akshata Moghe; Madhuvanti Patil; David F Barker; Leila Gobejishvili; Guy N Brock; Matthew Cave; Craig J McClain; Shirish S Barve
Journal:  J Immunol       Date:  2014-06-04       Impact factor: 5.422

4.  Effects of ethanol consumption and withdrawal on B cell subpopulations in murine bone marrow.

Authors:  T E Kruger; T R Jerrells
Journal:  Clin Exp Immunol       Date:  1994-06       Impact factor: 4.330

5.  Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression.

Authors:  Prachi T Hote; Rashmita Sahoo; Tanvi S Jani; Smita S Ghare; Theresa Chen; Swati Joshi-Barve; Craig J McClain; Shirish S Barve
Journal:  J Nutr Biochem       Date:  2007-09-14       Impact factor: 6.048

6.  Study of the factors that cause specific transformation in cultures of lymphocytes from patients with quinine- and quinidine-induced immune thrombocytopenia.

Authors:  P K Hosseinzadeh; B G Firkin; S L Pfueller
Journal:  J Clin Invest       Date:  1980-10       Impact factor: 14.808

Review 7.  AIDS, drugs of abuse and the immune system: a complex immunotoxicological network.

Authors:  R Pillai; B S Nair; R R Watson
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153
  7 in total

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