Literature DB >> 421848

Dose-effects of 8-methoxypsoralen and long wave UV-light in 3T3 cells: evaluation of phototoxic index.

J Pohl, E Christophers.   

Abstract

3T3 cells were cultured until confluency and treated with various doses of 8-methoxypsoralen followed by long wave UV light irradiation. The inhibition of 3H-thymidine incorporation was dose-dependent for both, psoralen and light. A phototoxic index (PTI) was established demonstrating that a constant correlation between psoralen and UVA light exists for the photoinactivation in living cells.

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Year:  1979        PMID: 421848     DOI: 10.1007/bf01920643

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  7 in total

1.  Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.

Authors:  J A Parrish; T B Fitzpatrick; L Tanenbaum; M A Pathak
Journal:  N Engl J Med       Date:  1974-12-05       Impact factor: 91.245

2.  DNA cross-linking in Chinese hamster cells exposed to near ultraviolet light in the presence of 4,5',8-trimethylpsoralen.

Authors:  E Ben-Hur; M M Elkind
Journal:  Biochim Biophys Acta       Date:  1973-12-07

3.  Studies on the photoreactions (365 nm) between DNA and some methylpsoralens.

Authors:  F Dall'Acqua; S Marciani; D Vedaldi; G Rodighiero
Journal:  Biochim Biophys Acta       Date:  1974-07-11

4.  Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.

Authors:  R S Cole
Journal:  Biochim Biophys Acta       Date:  1970-09-17

5.  Psoralen monoadducts and interstrand cross-links in DNA.

Authors:  R S Cole
Journal:  Biochim Biophys Acta       Date:  1971-11-29

6.  [Photochemotherapy of psoriasis: clinical experiences with 152 patients (author's transl)].

Authors:  K Wolff; H Hönigsmann; F Gschnait; K Konrad
Journal:  Dtsch Med Wochenschr       Date:  1975-11-28       Impact factor: 0.628

7.  Photosensitization of skin in vivo by furocoumarins (psoralens).

Authors:  M A Pathak; D M Krämer
Journal:  Biochim Biophys Acta       Date:  1969-11-19
  7 in total

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