Literature DB >> 42176

Standardization of the alkaline elution procedure using X-ray-damaged nuclear DNA.

C Bolognesi, C F Cesarone, L Santi.   

Abstract

Structural modification of DNA were induced by X-irradiation of crude hepatic nuclei at various dose ranges to standardize DNA damage evaluated by the alkaline elution technique. This quantitative assay can be used as reference for DNA damage induced by the in vivo administration of mutagens and/or carcinogens involved in the environment.

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Year:  1979        PMID： 42176     DOI： 10.1177/030089167906500501

Source DB:  PubMed          Journal:  Tumori        ISSN： 0300-8916


  4 in total

1.  Synthesis, antitumor activity, distribution and toxicity of 4-[4-[bis(2-chloroethyl)amino]phenyl]-1-hydroxybutane-1 1-bisphosphonic acid (BAD), a new lost derivative with increased accumulation in rat osteosarcoma.

Authors:  F Wingen; H Sterz; H Blum; H Möller; W Pittermann; B L Pool; H J Sinn; H Spring; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

2.  The level of DNA interstrand crosslinking in bone marrow parallels the extent of myelosuppression in mice treated with four chloroethylnitrosoureas.

Authors:  P Bedford; M R Berger; G Eisenbrand; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

3.  Comparison of DNA damage in various tissues, myelosuppression and serum levels of transaminases and bilirubin in tumor-bearing female Sprague-Dawley rats treated with 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (HECNU).

Authors:  T Henne; M R Berger
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

4.  Experiments on the efficacy and toxicity of locoregional chemotherapy of liver tumors with 5-fluoro-2'-deoxyuridine (FUDR) and 5-fluorouracil (5-FU) in an animal model.

Authors:  R Bartkowski; M R Berger; J L Aguiar; T H Henne; J Dörsam; G H Geelhaar; P Schlag; C Herfarth
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553
  4 in total

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