Literature DB >> 4214831

Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites.

H M Bolt, H Kappus, R Käsbohrer.   

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Year:  1974        PMID: 4214831     DOI: 10.1210/jcem-39-6-1072

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN: 0021-972X            Impact factor:   5.958


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  11 in total

1.  Effects of cytochrome P450 inducers on 17alpha-ethinyloestradiol (EE2) conjugation by primary human hepatocytes.

Authors:  A P Li; N R Hartman; C Lu; J M Collins; J M Strong
Journal:  Br J Clin Pharmacol       Date:  1999-11       Impact factor: 4.335

2.  Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl.

Authors:  A Wade; A M Symons; L Martin; D V Parke
Journal:  Biochem J       Date:  1979-12-15       Impact factor: 3.857

Review 3.  Clinical pharmacokinetics of oral contraceptive steroids.

Authors:  M L Orme; D J Back; A M Breckenridge
Journal:  Clin Pharmacokinet       Date:  1983 Mar-Apr       Impact factor: 6.447

4.  Effect of rifampicin treatment on the metabolism of oestradiol and 17alpha-ethinyloestradiol by human liver microsomes.

Authors:  H M Bolt; H Kappus; M Bolt
Journal:  Eur J Clin Pharmacol       Date:  1975-06-13       Impact factor: 2.953

5.  Anti-oestrogen antibodies in users of oral contraceptives and in patients with systemic lupus erythematosus.

Authors:  R Bucala; R G Lahita; J Fishman; A Cerami
Journal:  Clin Exp Immunol       Date:  1987-01       Impact factor: 4.330

6.  The significance of covalent binding of catechols to proteins in vivo.

Authors:  H Remmer; M Scheulen; H Kappus; H M Bolt
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

7.  The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.

Authors:  H S Purba; J L Maggs; M L Orme; D J Back; B K Park
Journal:  Br J Clin Pharmacol       Date:  1987-04       Impact factor: 4.335

8.  2-Hydroxylation of ethinyloestradiol in relation to the oxidation of sparteine and antipyrine.

Authors:  D J Back; J L Maggs; H S Purba; S Newby; B K Park
Journal:  Br J Clin Pharmacol       Date:  1984-10       Impact factor: 4.335

Review 9.  Interindividual variation and drug interactions with hormonal steroid contraceptives.

Authors:  D J Back; A M Breckenridge; F E Crawford; M MacIver; M L Orme; P H Rowe
Journal:  Drugs       Date:  1981-01       Impact factor: 9.546

10.  Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 alpha-ethinyloestradiol. Relative activities of rat and human liver enzymes.

Authors:  S E Ball; L M Forrester; C R Wolf; D J Back
Journal:  Biochem J       Date:  1990-04-01       Impact factor: 3.857

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