| Literature DB >> 421230 |
G A Frick, R Ballentine, C W Driever, W G Kramer.
Abstract
The effect of hydration and mannitol diuresis on the nephrotoxicity and renal excretion kinetics of high-dose cis-dichlorodiammineplatinum(II) was examined in seven men undergoing treatment for testicular or bladder carcinoma. The elimination half-life averaged 26.8 hours, shorter than values previously reported from studies not employing hydration and diuresis. In addition, no signs of nephrotoxicity were observed. The results suggest that hydration and mannitol diuresis decrease the nephrotoxicity of cis-dichlorodiammineplatinum(II) by increasing its rate of elimination.Entities:
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Year: 1979 PMID: 421230
Source DB: PubMed Journal: Cancer Treat Rep ISSN: 0361-5960