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Literature DB >> 4208506

Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin.

Abstract

Kanamycin, BB-K8, and gentamicin were tested in parallel against 1,037 bacterial strains isolated from clinical material. The activity of BB-K8 at 20 mug/ml was comparable to that of gentamicin at 8 mug/ml against Pseudomonas aeruginosa and against Enterobacteriaceae, with the exception of gentamicin-resistant strains of Proteus rettgeri and Providencia stuartii, in which case the activities of BB-K8 and kanamycin were the same. BB-K8 exhibited little or no activity against streptococci. The activity of BB-K8 was affected by pH and inoculum size. A regression graph for inhibition data with a 10-mug disk of BB-K8 was developed, and synergistic activity of penicillin and BB-K8 against Streptococcus faecalis was tested.

Entities: Chemical Species

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Year: 1973 PMID： 4208506 PMCID： PMC444518 DOI： 10.1128/AAC.4.2.133

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

1. The mutual effects of antimicrobial compounds and metallic cations.

Authors: E D WEINBERG
Journal: Bacteriol Rev Date: 1957-03

2. Reversal of the antibacterial activity of polymyxin by divalent cations.

Authors: B A NEWTON
Journal: Nature Date: 1953-07-25 Impact factor: 49.962

3. BB-K 8, a new semisynthetic aminoglycoside antibiotic.

Authors: H Kawaguchi; T Naito; S Nakagawa; K I Fujisawa
Journal: J Antibiot (Tokyo) Date: 1972-12 Impact factor: 2.649

4. Ototoxicity studies with BB-K8, a new semisynthetic aminoglycoside antibiotic.

Authors: J C Reiffenstein; S W Holmes; G H Hottendorf; M E Bierwagen
Journal: J Antibiot (Tokyo) Date: 1973-02 Impact factor: 2.649

5. In vitro susceptibility of staphylococci and streptococci and influence of agar media on minimum inhibitory concentration.

Authors: J A Washington; P E Hermans; W J Martin
Journal: Mayo Clin Proc Date: 1970-07 Impact factor: 7.616

6. Antibiotic susceptibility testing by a standardized single disk method.

Authors: A W Bauer; W M Kirby; J C Sherris; M Turck
Journal: Am J Clin Pathol Date: 1966-04 Impact factor: 2.493

7. Antibiotics synergism: enhanced susceptibility of group D streptococci to certain antibiotic combinations.

Authors: C J Wilkowske; R R Facklam; J A Washington; J E Geraci
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1970

8. In vitro susceptibility of gram-negative bacilli to gentamicin.

Authors: J A Washington; R E Ritts; W J Martin
Journal: Mayo Clin Proc Date: 1970-02 Impact factor: 7.616

9. Characterization of an unusual strain of proteus rettgeri associated with an outbreak of nosocomial urinary-tract infection.

Authors: W H Traub; M E Craddock; E A Raymond; M Fox; C E McCall
Journal: Appl Microbiol Date: 1971-09

10. Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin.

Authors: L P Garrod; P M Waterworth
Journal: J Clin Pathol Date: 1969-09 Impact factor: 3.411

15 in total

1. Penetration of amikacin into the aphakic eye.

Authors: R T Kasbeer; G A Peyman; D R May; P I Homer
Journal: Albrecht Von Graefes Arch Klin Exp Ophthalmol Date: 1975-08-04

2. Pharmacological evaluation of amikacin in neonates.

Authors: J B Howard; G H McCracken
Journal: Antimicrob Agents Chemother Date: 1975-07 Impact factor: 5.191

3. Activity of three aminoglycosides and two penicillins against four species of gram-negative bacilli.

Authors: R J Weinstein; L S Young; W L Hewitt
Journal: Antimicrob Agents Chemother Date: 1975-02 Impact factor: 5.191

4. Ototoxicity of amikacin.

Authors: R E Black; W K Lau; R J Weinstein; L S Young; W L Hewitt
Journal: Antimicrob Agents Chemother Date: 1976-06 Impact factor: 5.191

5. Antibiotic susceptibilities of human isolates of Pasteurella multocida.

Authors: D L Stevens; J W Higbee; T R Oberhofer; E D Everett
Journal: Antimicrob Agents Chemother Date: 1979-09 Impact factor: 5.191

6. In vitro activity, synergism, and testing parameters of amikacin, with comparisons to other aminoglycoside antibiotics.

Authors: M T Kelly; J M Matsen
Journal: Antimicrob Agents Chemother Date: 1976-03 Impact factor: 5.191

7. In vitro activity of gentamicin, amikacin and netilmicin alone and in combination with carbenicillin against Serratia marcescens.

Authors: S M Pogwizd; S A Lerner
Journal: Antimicrob Agents Chemother Date: 1976-12 Impact factor: 5.191