Literature DB >> 420821

Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma.

R G DiScipio, E W Davie.   

Abstract

Protein S is a vitamin K dependent protein of unknown function, which is present in mammalian plasma. It was isolated from bovine plasma by barium citrate adsorption and elution, ammonium sulfate fractionation, and column chromatography on DEAE-Sephadex, heparin-agarose, and polyhomoarginine-Sepharose. Bovine Protein S (Mr 64,200) is a single-chain glycoprotein with an amino-terminal sequence of Ala-Asn-Thr-Leu-Leu-. It contains 7.0% carbohydrate and 10 residues of gamma-carboxyglutamic acid per mol of protein. Human Protein S (Mr 69,000) is also a single-chain glycoprotein with an amino-terminal sequence of Ala-Asn-Ser-Leu-Leu-. It contains 7.8% carbohydrate and 10 residues of gamma-carboxyglutamic acid per mol of protein. These results indicate that Protein S from bovine or human plasma shows many similarities to the other vitamin K dependent proteins present in plasma.

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Year:  1979        PMID： 420821     DOI： 10.1021/bi00572a026

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  39 in total

1.  Total chemical synthesis of enzymatically active human type II secretory phospholipase A2.

Authors:  T M Hackeng; C M Mounier; C Bon; P E Dawson; J H Griffin; S B Kent
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

Review 2.  The interaction between complement component C4b-binding protein and the vitamin K-dependent protein S forms a link between blood coagulation and the complement system.

Authors:  M Hessing
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

3.  Characterization of mini-protein S, a recombinant variant of protein S that lacks the sex hormone binding globulin-like domain.

Authors:  M Van Wijnen; J G Stam; G T Chang; J C Meijers; P H Reitsma; R M Bertina; B N Bouma
Journal:  Biochem J       Date:  1998-02-15       Impact factor: 3.857

4.  Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain.

Authors:  D Borgel; P Gaussem; C Garbay; C Bachelot-Loza; T Kaabache; W Q Liu; B Brohard-Bohn; B Le Bonniec; M Aiach; S Gandrille
Journal:  Biochem J       Date:  2001-12-01       Impact factor: 3.857

5.  Vitamin K-dependent protein S is similar to rat androgen-binding protein.

Authors:  M E Baker; F S French; D R Joseph
Journal:  Biochem J       Date:  1987-04-01       Impact factor: 3.857

6.  Primary structure of bovine vitamin K-dependent protein S.

Authors:  B Dahlbäck; A Lundwall; J Stenflo
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

7.  Development of an electrospun biomimetic polyurea scaffold suitable for vascular grafting.

Authors:  Krishna Madhavan; Maria G Frid; Kendall Hunter; Robin Shandas; Kurt R Stenmark; Daewon Park
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2017-01-27       Impact factor: 3.368

8.  Human Protein Z.

Authors:  G J Broze; J P Miletich
Journal:  J Clin Invest       Date:  1984-04       Impact factor: 14.808

9.  Comparison of amino acid sequence of bovine coagulation Factor IX (Christmas Factor) with that of other vitamin K-dependent plasma proteins.

Authors:  K Katayama; L H Ericsson; D L Enfield; K A Walsh; H Neurath; E W Davie; K Titani
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

10.  [The clinical importance of protein C and S deficiency for surgical patients].

Authors:  H Rabl; H Fruhwirth
Journal:  Langenbecks Arch Chir       Date:  1992
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