Literature DB >> 4206907

A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors.

A Cornish-Bowden.   

Abstract

A new method is described for plotting kinetic results for inhibited enzyme-catalysed reactions. It provides a simple way of determining the inhibition constant, K'(i), of an uncompetitive, mixed or non-competitive inhibitor.

Mesh：

Substances：

Year:  1974        PMID： 4206907      PMCID： PMC1166095          DOI： 10.1042/bj1370143

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  5 in total

1.  A COMPARISON OF ESTIMATES OF MICHAELIS-MENTEN KINETIC CONSTANTS FROM VARIOUS LINEAR TRANSFORMATIONS.

Authors:  J E DOWD; D S RIGGS
Journal:  J Biol Chem       Date:  1965-02       Impact factor: 5.157

2.  Statistical estimations in enzyme kinetics.

Authors:  G N WILKINSON
Journal:  Biochem J       Date:  1961-08       Impact factor: 3.857

3.  Statistical analysis of enzymic steady-state rate data.

Authors:  G JOHANSEN; R LUMRY
Journal:  C R Trav Lab Carlsberg       Date:  1961

4.  The determination of enzyme inhibitor constants.

Authors:  M DIXON
Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

5.  Limitations of he Dixon plot for ascertaining naure of enzyme inhibition.

Authors:  M Schlamowitz; A Shaw; W T Jackson
Journal:  Tex Rep Biol Med       Date:  1969
  5 in total
  165 in total

1.  Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data.

Authors:  A Cortés; M Cascante; M L Cárdenas; A Cornish-Bowden
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857

2.  Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals.

Authors:  R A Cunha
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

3.  Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase.

Authors:  P Masson; M T Froment; C F Bartels; O Lockridge
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

4.  tRNA-guanine transglycosylase from E. coli: a ping-pong kinetic mechanism is consistent with nucleophilic catalysis.

Authors:  DeeAnne M Goodenough-Lashua; George A Garcia
Journal:  Bioorg Chem       Date:  2003-08       Impact factor: 5.275

5.  Inhibitors of imipramine metabolism by human liver microsomes.

Authors:  E Skjelbo; K Brøsen
Journal:  Br J Clin Pharmacol       Date:  1992-09       Impact factor: 4.335

6.  Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).

Authors:  G J Peters; S L Sharma; E Laurensse; H M Pinedo
Journal:  Invest New Drugs       Date:  1987       Impact factor: 3.850

7.  Inhibition of Sodium-Hydrogen Antiport by Antibodies to NHA1 in Brush Border Membrane Vesicles from Whole Aedes aegypti Larvae.

Authors:  Kenneth M Sterling; William R Harvey
Journal:  J Membr Biol       Date:  2018-11-03       Impact factor: 1.843

8.  Eosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum.

Authors:  Kristen M Massimine; Michael T McIntosh; Lanxuan T Doan; Chloé E Atreya; Stephan Gromer; Worachart Sirawaraporn; David A Elliott; Keith A Joiner; R Heiner Schirmer; Karen S Anderson
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

9.  N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-beta-lactamase.

Authors:  Stefan Siemann; Darryl P Evanoff; Laura Marrone; Anthony J Clarke; Thammaiah Viswanatha; Gary I Dmitrienko
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

10.  Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases.

Authors:  Florian Veillard; Maryta Sztukowska; Danuta Mizgalska; Mirosław Ksiazek; John Houston; Barbara Potempa; Jan J Enghild; Ida B Thogersen; F Xavier Gomis-Rüth; Ky-Anh Nguyen; Jan Potempa
Journal:  Biochim Biophys Acta       Date:  2013-04-10
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.