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Literature DB >> 4205196

Regulation of aconitase synthesis in Bacillus subtilis: induction, feedback repression, and catabolite repression.

Abstract

The synthesis of aconitase in Bacillus subtilis wild-type and different citric acid cycle mutants has been studied and the influence of various growth conditions examined. Aconitase is induced by citrate and precursors of citrate and repressed by glutamate. Induction and repression counteract each other, and at equimolar concentrations of citrate and glutamate, aconitase synthesis is unaffected. Induction by citrate can partly overcome catabolite repression of aconitase. Isocitrate dehydrogenase show endogenous induction of aconitase due to citrate accumulation. Leaky mutants defective in citrate synthase and aconitase cannot be induced by citrate, which indicates that they carry a regulatory mutation. The complex regulation of aconitase is discussed with reference to the participation of this enzyme in glutamate biosynthesis and energy metabolism.

Entities: Chemical Species

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Year: 1974 PMID： 4205196 PMCID： PMC246613 DOI： 10.1128/jb.117.3.1295-1305.1974

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

26 in total

Regulation of aconitase synthesis in Bacillus subtilis: induction, feedback repression, and catabolite repression.

1. THE DEVELOPMENTAL SIGNIFICANCE OF ALANINE DEHYDROGENASE IN BACILLUS SUBTILIS.

2. REQUIREMENTS FOR TRANSFORMATION IN BACILLUS SUBTILIS.

3. Catabolite repression of aconitate hydratase in Bacillus subtilis.

4. Production of adenosine triphosphate in normal cells and sporulation mutants of Bacillus subtilis.

5. The regulation of aconitase and isocitrate dehydrogenase in sporulation mutants of Bacillus subtilis.

6. Inducible transport of citrate in a Gram-positive bacterium, Bacillus subtilis.

7. Coarse and fine control of citrate synthase from Bacillus subtilis.

8. Spore pool glutamic acid as a metabolite in germination.

9. Effect of different nutritional conditions on the synthesis of tricarboxylic acid cycle enzymes.

10. Growth and sporulation of Bacillus subtilis mutants blocked in the pyruvate dehydrogenase complex.

1. Complex regulation of the Bacillus subtilis aconitase gene.

2. Catabolite repression and induction of the Mg(2+)-citrate transporter CitM of Bacillus subtilis.

3. Characteristics of Bacillus stearothermophilus mutants blocked in catabolic function.

4. Roles of aconitase in growth, metabolism, and morphological differentiation of Streptomyces coelicolor.

5. A target for carbon source-dependent negative regulation of the citB promoter of Bacillus subtilis.

6. Regulation of citrate synthase activity of Saccharomyces cerevisiae.

7. Multiple regulatory sites in the Bacillus subtilis citB promoter region.

8. Synthesis of oxaloacetate in Bacillus subtilis mutants lacking the 2-ketoglutarate dehydrogenase enzymatic complex.

9. Regulation of the dicarboxylic acid part of the citric acid cycle in Bacillus subtilis.

10. 2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis.