Literature DB >> 4205

Effect of metiamide on acid secretion from isolated kitten fundic mucosa.

B L Tepperman, B Schofield, F S Tepperman.   

Abstract

Isolated kitten fundic mucosa demonstrates low rates of spontaneous acid secretion in vitro when bathed in Krebs-Henseleit solution, and responds consistently to histamine, pentagastrin, and acetylcholine placed in the bath. High rates of spontaneous secretion or secretion in response to histamine and pentagastrin were significantly inhibited by addition of metiamide (5 X 10(-3) M); but mucosa stimulated by constant addition of acetylcholine chloride (10(-4) M) was not inhibited by metiamide at the same concentration.

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Year:  1975        PMID: 4205     DOI: 10.1139/y75-159

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN: 0008-4212            Impact factor:   2.273


  15 in total

1.  Theophylline-induced fluid and electrolyte sectetion by rabbit ileum results from negative anomalous osmotic flow across the tight-junction [proceedings].

Authors:  G D Holman; R J Naftalin
Journal:  J Physiol       Date:  1976-12       Impact factor: 5.182

2.  Pharmacological analysis of the muscarinic receptors involved when McN-A 343 stimulates acid secretion in the mouse isolated stomach.

Authors:  J W Black; N P Shankley
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

3.  The isolated stomach preparation of the mouse: a physiological unit for pharmacological analysis.

Authors:  J W Black; N P Shankley
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

4.  Is pentagastrin-stimulated secretion mediated by histamine?

Authors:  W K Man; C J Ingoldby; J Spencer
Journal:  Gut       Date:  1984-09       Impact factor: 23.059

5.  Analysis of anomalous pKb values for metiamide and atropine in the isolated stomach of the mouse.

Authors:  J A Angus; J W Black
Journal:  Br J Pharmacol       Date:  1979-09       Impact factor: 8.739

6.  Inhibitory effect of cimetidine on gastric acid secretion vagally activated by physiological means in duodenal ulcer patients.

Authors:  I M Schöön; L Olbe
Journal:  Gut       Date:  1978-01       Impact factor: 23.059

7.  Acid secretion by isolated canine gastric mucosa.

Authors:  Y J Kuo; L L Shanbour
Journal:  J Physiol       Date:  1978-12       Impact factor: 5.182

8.  Inhibition by metiamide of secretagogue-induced gastric acid secretion in the conscious Heidenhain pouch rat.

Authors:  K T Bunce; M E Parsons
Journal:  J Physiol       Date:  1978-12       Impact factor: 5.182

9.  Metiamide and stimulated acid secretion from the isolated non-distended and distended mouse stomach.

Authors:  B Y Wan
Journal:  J Physiol       Date:  1977-04       Impact factor: 5.182

Review 10.  Cimetidine: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1978-02       Impact factor: 9.546

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