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Literature DB >> 4203489

Cerebroside antibody inhibits sulfatide synthesis and myelination and demyelinates in cord tissue cultures.

J M Fry, S Weissbarth, G M Lehrer, M B Bornstein.

Abstract

Antiserum to cerebroside was prepared in rabbits by injection of cerebroside together with bovine serum albumin in complete Freund's adjuvant. When applied to cultures of embryo mouse spinal cord at explantation, this antiserum inhibited sulfatide synthesis and myelination; when applied to myelinated cultures it inhibited sulfatide synthesis and produced demyelination. Complement fixation assays also show antibody to cerebroside in serums from rabbits with experimental allergic encephalomyelitis induced by injection of whole white matter. Absorption of such serum with cerebroside abolishes the inhibiting and demyelinating activities.

Entities: Chemical Disease Gene Species

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Year: 1974 PMID： 4203489 DOI： 10.1126/science.183.4124.540

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

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5. In vivo effect of sera from animals with chronic relapsing experimental allergic encephalomyelitis on central and peripheral myelin.

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Cerebroside antibody inhibits sulfatide synthesis and myelination and demyelinates in cord tissue cultures.

Review 1. What's new in the pathogenesis of multiple sclerosis? A review.

2. Tenascin-R is an intrinsic autocrine factor for oligodendrocyte differentiation and promotes cell adhesion by a sulfatide-mediated mechanism.

3. Shared antigenic determinants between brain and thymus-derived lymphocytes in dogs.

Review 4. Novel oligodendrocyte transmembrane signaling systems. Investigations utilizing antibodies as ligands.

5. In vivo effect of sera from animals with chronic relapsing experimental allergic encephalomyelitis on central and peripheral myelin.

6. Demyelination in the spinal cord of murine globoid cell leukodystrophy (the twitcher mouse).

7. Chronic relapsing experimental allergic encephalomyelitis: its value as an experimental model for multiple sclerosis.

8. Immunological reactions against Mycoplasma pneumoniae in multiple sclerosis: preliminary findings.

9. Adult CST-null mice maintain an increased number of oligodendrocytes.

10. In vivo demyelination induced by intraneural injection of anti-galactocerebroside serum: a morphologic study.