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Literature DB >> 4202891

Reactivity of purified proteins and polysaccharides from Mycobacterium tuberculosis in delayed skin test and cultured lymphocyte mitogenesis assays.

Abstract

Hypersensitivity responses to two highly purified and well characterized mycobacterial proteins and a preparation of mycobacterial arabinogalactanarabinomannan were studied by using guinea pig skin tests and in vitro-cultured human lymphocyte mitogenesis stimulation assays. The purified proteins were found to elicit delayed-type hypersensitivity skin test reactions and to stimulate mitogenesis in cultured lymphocytes. The polysaccharide preparation was found to evoke delayed skin tests but not to stimulate cultured lymphocytes.

Entities: Chemical Disease Species

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Year: 1974 PMID： 4202891 PMCID： PMC414762 DOI： 10.1128/iai.9.1.44-47.1974

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

17 in total

1. THE IMMUNOLOGY AND CHEMISTRY OF TUBERCULIN. II. CHROMATOGRAPHY WITH SEPHADEX OF THE NONDIALYZABLE TUBERCULIN-ACTIVE CONSTITUENTS OF BCG CULTURE FILTRATE.

Authors: S D CHAPARAS; H BAER
Journal: Am Rev Respir Dis Date: 1964-01

2. Tuberculin-induced mitosis in peripheral blood leucocytes.

Authors: G PEARMAIN; R R LYCETTE; P H FITZGERALD
Journal: Lancet Date: 1963-03-23 Impact factor: 79.321

3. A modified technique of immunoelectrophoresis facilitating the identification of specific precipitin arcs.

Authors: E F OSSERMAN
Journal: J Immunol Date: 1960-01 Impact factor: 5.422

4. Correlation of lymphocyte transformation with tuberculin skin-test sensitivity.

Authors: S D Miller; H E Jones
Journal: Am Rev Respir Dis Date: 1973-04

5. Factors influencing the stimulation of human lymphocytes by antigen during culture in vitro. Conditions for lymphocyte stimulation.

Authors: C F Hinz; J F Chickosky
Journal: Int Arch Allergy Appl Immunol Date: 1972

6. Mitogenic activity of bacterial fractions in lymphocyte cultures. I. Purified protein derivative and polysaccharides of tuberculin.

Authors: D H Heilman; W McFarland
Journal: J Immunol Date: 1966-06 Impact factor: 5.422

7. Quantitative aspects of the stimulation of lymphocytes by tuberculin purified protein derivative.

Authors: C F Hinz; T M Daniel; G L Baum
Journal: Int Arch Allergy Appl Immunol Date: 1970

8. Immunological reactivity of a synthetic polymannan.

Authors: S F Grappel
Journal: Experientia Date: 1971-03-15

9. Skin reactivity of human subjects to a polysaccharide component of BCG culture filtrates.

Authors: R K Root; S M Wolff; H Baer
Journal: Proc Soc Exp Biol Med Date: 1971-02

10. A reference system for antigens of Mycobacterium tuberculosis.

Authors: B W Janicki; S D Chaparas; T M Daniel; G P Kubica; G L Wright; G S Yee
Journal: Am Rev Respir Dis Date: 1971-10

11 in total

1. Immunosuppression by mycobacterial arabinomannan.

Authors: J J Ellner; T M Daniel
Journal: Clin Exp Immunol Date: 1979-02 Impact factor: 4.330

2. Identification of an immunostimulating protein from Mycobacterium leprae.

Authors: N Mohagheghpour; M W Munn; R H Gelber; E G Engleman
Journal: Infect Immun Date: 1990-03 Impact factor: 3.441

Review 3. Mycobacterial antigens: a review of their isolation, chemistry, and immunological properties.

Authors: T M Daniel; B W Janicki
Journal: Microbiol Rev Date: 1978-03

4. Whole-blood lymphocyte stimulation assay for measurement of cell-mediated immune responses in bovine brucellosis.

Authors: J M Kaneene; R K Anderson; D W Johnson; C C Muscoplat; P Nicoletti; R D Angus; D E Pietz; D J Klausner
Journal: J Clin Microbiol Date: 1978-06 Impact factor: 5.948

5. Utilization of a specific in vitro lymphocyte immunostimulation assay as an aid in detection of brucella-infected cattle not detected by serological tests.

Authors: J M Kaneene; D W Johnson; R K Anderson; C C Muscoplat
Journal: J Clin Microbiol Date: 1978-11 Impact factor: 5.948