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Literature DB >> 4202340

Screening and isolation of penicillinase inhibitor, KA-107.

Y Iwai, H Ono, H Takeshima, N Yamaguchi, S Omura.

Abstract

It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptomyces gedanensis ATCC 4880 a penicillinase inhibitor, named KA-107, was isolated. The characteristics of this inhibitor were revealed by an in vitro test by using penicillinase derived from penicillin resistant Staphylococcus aureus, FS-1277. When KA-107 was used in combination with penicillin-G, ampicillin, d- or l-phenethicillin, the growth inhibitory activity of these penicillins was maintained.

Entities: Chemical Species

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Year: 1973 PMID： 4202340 PMCID： PMC444532 DOI： 10.1128/AAC.4.3.222

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

1. [Purification and physicochemical characteristics of the penicillinase of Bacillus cereus].

Authors: M R POLLOCK; A M TORRIANI
Journal: C R Hebd Seances Acad Sci Date: 1953-07-20

2. THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLI.

Authors: Y Hirota
Journal: Proc Natl Acad Sci U S A Date: 1960-01 Impact factor: 11.205

3. Activity of distamycin A on the transfer of drug resistance in gram-negative clinical isolates.

Authors: A Sanfilippo
Journal: Ann N Y Acad Sci Date: 1971-06-11 Impact factor: 5.691

4. The problems of drug-resistant pathogenic bacteria. Elimination of bacterial episomes by DNA-complexing compounds.

Authors: F E Hahn; J Ciak
Journal: Ann N Y Acad Sci Date: 1971-06-11 Impact factor: 5.691

5. The problems of drug-resistant pathogenic bacteria. In vitro and in vivo methodology for detecting and evaluating inhibitors of transfer of resistance factors.

Authors: J L Ott; L J Short; D H Holmes
Journal: Ann N Y Acad Sci Date: 1971-06-11 Impact factor: 5.691

1. Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.

Authors: N G Brown; T Palzkill
Journal: Protein Eng Des Sel Date: 2010-03-22 Impact factor: 1.650

2. In vitro and in vivo activity of penicillinase inhibitor KA-107 against Staphylococcus aureus FS-1277.

Authors: H Ono; A Matsumae; Y Iwai; M Nakae; S Omura
Journal: Antimicrob Agents Chemother Date: 1973-09 Impact factor: 5.191

2 in total

Screening and isolation of penicillinase inhibitor, KA-107.

1. [Purification and physicochemical characteristics of the penicillinase of Bacillus cereus].

2. THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLI.

3. Activity of distamycin A on the transfer of drug resistance in gram-negative clinical isolates.

4. The problems of drug-resistant pathogenic bacteria. Elimination of bacterial episomes by DNA-complexing compounds.

5. The problems of drug-resistant pathogenic bacteria. In vitro and in vivo methodology for detecting and evaluating inhibitors of transfer of resistance factors.

6. Studies on penicillinase inhibitors produced by microorganisms.

7. The increased rate of loss of penicillinase plasmids from Staphylococcus aureus in the presence of rifampicin.

8. The demonstration and significance of synergism between -lactam antibiotics.

9. Synthesis of 3'-deoxykanamycin effective against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosa.

10. Inhibition of the -lactamases of Escherichia coli and Klebsiella aerogenes by semi-synthetic penicillins.

1. Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.

2. In vitro and in vivo activity of penicillinase inhibitor KA-107 against Staphylococcus aureus FS-1277.