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Literature DB >> 4200778

An electrophoretic difference between surface and secreted IgM of murine splenocytes.

Abstract

micro-chains on the surface of murine splenocytes are more heterogeneous on SDS-polyacrylamide gel electrophoresis than both secreted and intracellular micro-chains labeled with [(3)H]tyrosine. No difference in heterogeneity among cell surface, secreted, or intracellular L chains was detected. The possible role of carbohydrate in micro-chain heterogeneity is discussed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1973 PMID： 4200778 PMCID： PMC2139427 DOI： 10.1084/jem.138.5.1282

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

17 in total

1. Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis.

Authors: J P Segrest; R L Jackson; E P Andrews; V T Marchesi
Journal: Biochem Biophys Res Commun Date: 1971-07-16 Impact factor: 3.575

2. The synthesis and secretion of gamma-globulin by lymph node cells. 3. The slow acquisition of the carbohydrate moiety of gamma-globulin and its relationship to secretion.

Authors: R M Swenson; M Kern
Journal: Proc Natl Acad Sci U S A Date: 1968-02 Impact factor: 11.205

7. Immunoglobulin synthesis and secretion, IV. Sites of incorporation of sugars as determined by subcellular fractionation.

Authors: J W Uhr; I Schenkein
Journal: Proc Natl Acad Sci U S A Date: 1970-07 Impact factor: 11.205

An electrophoretic difference between surface and secreted IgM of murine splenocytes.

1. Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis.

2. The synthesis and secretion of gamma-globulin by lymph node cells. 3. The slow acquisition of the carbohydrate moiety of gamma-globulin and its relationship to secretion.

3. Intracellular events underlying synthesis and secretion of immunoglobulin.

4. Immunoglobulin biosynthesis. IV. Carbohydrate attachment to immunoglobulin subunits.

5. Variation and homology in imunoglobulin heavy chains.

6. Isolation and partial characterization of lymphocyte surface immunoglobulins.

7. Immunoglobulin synthesis and secretion, IV. Sites of incorporation of sugars as determined by subcellular fractionation.

8. Biosynthesis of the carbohydrate portions of immunoglobulin M.

9. Lymphocyte membrane dynamics. Metabolic release of cell surface proteins.

10. Cell surface immunoglobulin. II. Isolation and characterization of immunoglobulin from mouse splenic lymphocytes.

1. Possible palindromes in immunoglobulin heavy-chain genes: Their role in membrane attachment.

2. Density comparisons of heavy chains of membrane and secreted immunoglobulins of mouse.