Literature DB >> 4200486

A new antitumor antimetabolite, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): antimicrobial reversal studies and preliminary evaluation against L1210 mouse leukemia in vivo.

L J Hanka, D G Martin, G L Neil.   

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Year:  1973        PMID： 4200486

Source DB:  PubMed          Journal:  Cancer Chemother Rep        ISSN： 0069-0112


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  6 in total

1.  Improved methods for production, isolation, and assay of two new chlorisoxazoline amino acid antitumor antimetabolites: U-42, 126 and U43, 795.

Authors:  L J Hanka; S A Gerpheid; P R Spieles; D G Martin; P A Belter; T A Coleman; H F Meyer
Journal:  Antimicrob Agents Chemother       Date:  1975-06       Impact factor: 5.191

2.  Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.

Authors:  B Ardalan; B Chandrasekaran; H J Hrishikeshavan
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

3.  Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12.

Authors:  D R Smulski; L L Huang; M P McCluskey; M J Reeve; A C Vollmer; T K Van Dyk; R A LaRossa
Journal:  J Bacteriol       Date:  2001-06       Impact factor: 3.490

4.  Intracerebral chemotherapy in the 9L rat brain tumor model.

Authors:  B F Kimler; C Liu; R G Evans; R A Morantz
Journal:  J Neurooncol       Date:  1992-11       Impact factor: 4.130

5.  Inhibition of gamma-glutamyl transpeptidase and induction of glutathionuria by gamma-glutamyl amino acids.

Authors:  M E Anderson; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

6.  Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition†Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. See DOI: 10.1039/c4sc02339k.

Authors:  Johannes Kreuzer; Nina C Bach; Daniel Forler; Stephan A Sieber
Journal:  Chem Sci       Date:  2014-09-26       Impact factor: 9.825
  6 in total

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