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Literature DB >> 4199744

Trial of chloramphenicol for meningitis in northern savanna of Africa.

H C Whittle, N M Davidson, B M Greenwood, D A Warrell, A Tomkins, P Tugwell, A Zalin, A D Bryceson, E H Parry, M Brueton, M Duggan, A D Rajković.

Abstract

In a controlled trial chloramphenicol proved as effective and much cheaper than penicillin for the treatment of group A meningococcal meningitis in Zaria, Nigeria. A short course of five days cured most patients. Adults and older children were soon able to take chloramphenicol by mouth, which reduced the cost and simplified treatment.It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1973 PMID： 4199744 PMCID： PMC1586699 DOI： 10.1136/bmj.3.5876.379

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

10 in total

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Authors: T C EICKHOFF; M FINLAND
Journal: N Engl J Med Date: 1965-02-25 Impact factor: 91.245

2. Therapeutic range of chloramphenicol in purulent meningitis.

Authors: R T PARKER; M J SNYDER; R S LIU; J W LOOPER; T E WOODWARD
Journal: Antibiotic Med Clin Ther (New York) Date: 1955-04

3. Treatment of meningitis with chloromycetin palmitate; results of therapy in twenty-three cases.

Authors: G E DEANE; J E FURMAN; A R BENTZ; T E WOODWARD
Journal: Pediatrics Date: 1953-04 Impact factor: 7.124

4. Counter-current immunoelectrophoresis in the diagnosis of meningococcal infections.

Authors: B M Greenwood; H C Whittle; O Dominic-Rajkovic
Journal: Lancet Date: 1971-09-04 Impact factor: 79.321

5. Efficacy of intramuscular chloramphenicol in treatment of H. influenzae meningitis.

Authors: N K Bulos
Journal: J Pediatr Date: 1972-08 Impact factor: 4.406

6. General review of the treatment of meningitis.

Authors: K Sorensen
Journal: J Egypt Public Health Assoc Date: 1969

7. Statewide study of chloramphenicol therapy and fatal aplastic anemia.

Authors: R O Wallerstein; P K Condit; C K Kasper; J W Brown; F R Morrison
Journal: JAMA Date: 1969-06-16 Impact factor: 56.272

8. Evaluation of chloramphenicol acid succinate therapy of induced typhoid fever and rocky mountain spotted fever.

Authors: H L DuPont; R B Hornick; C F Weiss; M J Snyder; T E Woodward
Journal: N Engl J Med Date: 1970-01-08 Impact factor: 91.245

9. Sulfa-drug resistance and serologic studies of a meningococcal meningitis epidemic.

Authors: W R Sanborn
Journal: J Egypt Public Health Assoc Date: 1969

10. [Biological and clinical data concerning the reaction of Neisseria meningitides A to several sulfonamides and antibiotics: observations at Fort-Lamy (Chad) during a seasonal outbreak of cerebrospinal meningitis].

Authors: M Lefèvre; J Sirol; M Vandekerkove; R Faucon
Journal: Bull World Health Organ Date: 1969 Impact factor: 9.408

10 in total

5 in total

Trial of chloramphenicol for meningitis in northern savanna of Africa.

1. CHANGING SUSCEPTIBILITY OF MENINGOCOCCI TO ANTIMICROBIAL AGENTS.

2. Therapeutic range of chloramphenicol in purulent meningitis.

3. Treatment of meningitis with chloromycetin palmitate; results of therapy in twenty-three cases.

4. Counter-current immunoelectrophoresis in the diagnosis of meningococcal infections.

5. Efficacy of intramuscular chloramphenicol in treatment of H. influenzae meningitis.

6. General review of the treatment of meningitis.

7. Statewide study of chloramphenicol therapy and fatal aplastic anemia.

8. Evaluation of chloramphenicol acid succinate therapy of induced typhoid fever and rocky mountain spotted fever.

9. Sulfa-drug resistance and serologic studies of a meningococcal meningitis epidemic.

10. [Biological and clinical data concerning the reaction of Neisseria meningitides A to several sulfonamides and antibiotics: observations at Fort-Lamy (Chad) during a seasonal outbreak of cerebrospinal meningitis].

Review 1. Bacterial meningitis. Some aspects of diagnosis and treatment.

2. Sulbactam/ampicillin in the treatment of epidemic meningococcal meningitis in northern Nigeria.

3. Epidemic group C meningococcal meningitis in Upper Volta, 1979.

4. Characterization of epidemic and nonepidemic Neisseria meningitidis serogroup A strains from Sudan and Sweden.

Review 5. Rationale for optimal dosing of beta-lactam antibiotics in therapy for bacterial meningitis.