Literature DB >> 4198692

Inhibition of prostaglandin biosynthesis by 7-oxa- and 5-oxa-prostaglandin analogues.

R G McDonald-Gibson, J D Flack, P W Ramwell.   

Abstract

Some oxaprostaglandin derivatives have been shown to inhibit prostaglandin biosynthesis from arachidonate by a particulate prostaglandin synthetase preparation. The most potent inhibitor was 5-oxaprost-13-trans-enoate, and inhibition by this compound appeared to be competitive. Certain structure-activity relationships were ascertained.

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Year:  1973        PMID： 4198692      PMCID： PMC1177566          DOI： 10.1042/bj1320117

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS.

Authors:  K GREEN; B SAMUELSSON
Journal:  J Lipid Res       Date:  1964-01       Impact factor: 5.922

2.  Graphical analysis of single enzyme systems.

Authors:  B H HOFSTEE
Journal:  Enzymologia       Date:  1956-07-15

3.  The determination of enzyme inhibitor constants.

Authors:  M DIXON
Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

4.  Prostaglandin antagonists: synthesis and smooth muscle activity.

Authors:  J Fried; T S Santhanakrishnan; J Himizu; C H Lin; S H Ford; B Rubin; E O Grigas
Journal:  Nature       Date:  1969-07-12       Impact factor: 49.962

5.  Synthesis of (plus or minus)-7-oxaprostaglandin E1.

Authors:  J Fried; M M Mehra; W L Kao; C H Lin
Journal:  Tetrahedron Lett       Date:  1970-06       Impact factor: 2.415

6.  Enzyme inhibition by acetylenic compounds.

Authors:  D T Downing; D G Ahern; M Bachta
Journal:  Biochem Biophys Res Commun       Date:  1970-07-13       Impact factor: 3.575

7.  Biological activity of synthetic prostaglandins.

Authors:  P W Ramwell; J E Shaw; E J Corey; N Andersen
Journal:  Nature       Date:  1969-03-29       Impact factor: 49.962

8.  The biological activities of three metabolites of prostaglandin E 1.

Authors:  E Anggård
Journal:  Acta Physiol Scand       Date:  1966-04

9.  Inhibition of prostaglandin synthesis by oleic, linoleic and linolenic acids.

Authors:  C Pace-Asciak; L S Wolfe
Journal:  Biochim Biophys Acta       Date:  1968-07-01

10.  Synthesis and biological activity of prostaglandins and prostaglandin antagonists.

Authors:  J Fried; C Lin; M Mehra; W Kao; P Dalven
Journal:  Ann N Y Acad Sci       Date:  1971-04-30       Impact factor: 5.691
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