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Literature DB >> 4196634

Rabies group-specific ribonucleoprotein antigen and a test system for grouping and typing of rhabdoviruses.

L G Schneider, B Dietzschold, R E Dierks, W Matthaeus, P J Enzmann, K Strohmaier.

Abstract

Cell-associated ribonucleoprotein (RNP) was isolated from BHK-21 cells infected with several strains of rabies and rabies-related viruses. The RNP-antigen from rabies and related viruses induced the formation of complement-fixing, precipitating, and immunofluorescent antibodies, and proved to be the group-specific antigen common to all rabies viruses. Antigens of the envelope which induce virus-neutralizing antibodies are apparently determinative for the serotype of a virus as evidenced by two-way neutralization tests. A combination of these methods seems to be a useful approach to the serological grouping and typing of rhabdoviruses.

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Year: 1973 PMID： 4196634 PMCID： PMC355172

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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Journal: Proc Natl Acad Sci U S A Date: 2004-06-14 Impact factor: 11.205