Literature DB >> 4196324

Osmotic opening of the blood-brain barrier in the monkey without associated neurological deficits.

S I Rapoport, H K Thompson.   

Abstract

Hypertonic urea or lactamide solutions osmotically open the blood-brain barrier in the monkey without producing gross neurological deficits if the blood supply to the brain is not compromised. The brain is perfused via the left lingual artery when the external and common carotid arteries are clamped temporarily. Hypertonic perfusion, which opens the barrier by opening tight junctions between cerebrovascular endothelial cells, can thus be used to study barrier function and brain pharmacology.

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Year:  1973        PMID： 4196324     DOI： 10.1126/science.180.4089.971

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

Review 1.  Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications.

Authors:  S I Rapoport
Journal:  Cell Mol Neurobiol       Date:  2000-04       Impact factor: 5.046

Review 2.  Neuro-oncology index and review (adult primary brain tumors). Radiotherapy, chemotherapy, immunotherapy, photodynamic therapy.

Authors:  M S Mahaley
Journal:  J Neurooncol       Date:  1991-10       Impact factor: 4.130

3.  Morphological alterations and functional changes of interhepatocellular junctions induced by bile duct ligation.

Authors:  J Metz; A Aoki; M Merlo; W G Forssmann
Journal:  Cell Tissue Res       Date:  1977-08-26       Impact factor: 5.249

4.  Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis.

Authors:  Yu-Yo Sun; Dianer Yang; Chia-Yi Kuan
Journal:  J Neurosci Methods       Date:  2011-10-01       Impact factor: 2.390

Review 5.  Single compartment drug delivery.

Authors:  Michael J Cima; Heejin Lee; Karen Daniel; Laura M Tanenbaum; Aikaterini Mantzavinou; Kevin C Spencer; Qunya Ong; Jay C Sy; John Santini; Carl M Schoellhammer; Daniel Blankschtein; Robert S Langer
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6.  Convection-enhanced delivery of macromolecules in the brain.

Authors:  R H Bobo; D W Laske; A Akbasak; P F Morrison; R L Dedrick; E H Oldfield
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

7.  Modification of the blood-brain barrier: increased concentration and fate of enzymes entering the brain.

Authors:  J A Barranger; S I Rapoport; W R Fredericks; P G Pentchev; K D MacDermot; J K Steusing; R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

8.  Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes.

Authors:  Z L Chen; J A Indyk; T H Bugge; K W Kombrinck; J L Degen; S Strickland
Journal:  J Neurosci       Date:  1999-11-15       Impact factor: 6.167

Review 9.  Observations on exsudation of fibronectin, fibrinogen and albumin in the brain after carotid infusion of hyperosmolar solutions. An immunohistochemical study in the rat indicating longlasting changes in the brain microenvironment and multifocal nerve cell injuries.

Authors:  T S Salahuddin; H Kalimo; B B Johansson; Y Olsson
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

10.  Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison.

Authors:  R E Ruth; G S Feinerman
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088
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