Literature DB >> 4194767

The effect of hydrocortisone on immunoglobulin metabolism.

A L Levy, T A Waldmann.   

Abstract

The serum concentration of all subclasses of IgG (gamma(2)A, gamma(2)B, and gamma(1)) as well as IgA and IgM were reduced in normal and low pathogen mice receiving hydrocortisone acetate. Turnover studies using (131)I-labeled gamma(2)A subclass of IgG demonstrated that high dose corticosteroids cause a significantly shortened survival (increased catabolic rate) which contributes to the observed hypogammaglobulinemia. This increase in fractional catabolism is not due to excess loss in the urine or stool but reflects an increase in endogenous catabolism.

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 4194767      PMCID： PMC322651          DOI： 10.1172/JCI106385

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  15 in total

1.  QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES.

Authors:  J L FAHEY; E M MCKELVEY
Journal:  J Immunol       Date:  1965-01       Impact factor: 5.422

2.  The catabolism of 131I-labelled homologous gamma-globulin in normal, hyperthyroid and hypothyroid rats.

Authors:  C P FARTHING; J GERWING; J SHEWELL
Journal:  J Endocrinol       Date:  1960-09       Impact factor: 4.286

3.  The effects of adrenocortical hormones on albumin metabolism studied with albumin-I 131.

Authors:  M A ROTHSCHILD; S S SCHREIBER; M ORATZ; H L McGEE
Journal:  J Clin Invest       Date:  1958-09       Impact factor: 14.808

4.  The theory of tracer experiments with 131I-labelled plasma proteins.

Authors:  C M MATTHEWS
Journal:  Phys Med Biol       Date:  1957-07       Impact factor: 3.609

5.  Alterations in plasma proteins, plasma volume, and volume of packed red cells in patients receiving ACTH or cortisone.

Authors:  B V JAGER; H BROWN; M NICKERSON
Journal:  J Lab Clin Med       Date:  1951-03

6.  Failure of cortisone to affect rate of disappearance of antibody protein.

Authors:  E E FISCHEL; H C STOERK; M BJØRNEBOE
Journal:  Proc Soc Exp Biol Med       Date:  1951-05

7.  Systematic oscillations in tyrosine transaminase and other metabolic functions in liver of normal and adrenalectomized rats on controlled feeding schedules.

Authors:  M Watanabe; V R Potter; H C Pitot
Journal:  J Nutr       Date:  1968-06       Impact factor: 4.798

8.  Protein turnover and the regulation of enzyme levels in rat liver.

Authors:  R T Schimke
Journal:  Natl Cancer Inst Monogr       Date:  1967-11

9.  The effect of fever and corticotropin on the in vivo degradation of albumin in man as measured with iodinated human serum albumin.

Authors:  A L FLICK; J L STEINFELD
Journal:  Am J Med Sci       Date:  1958-07       Impact factor: 2.378

10.  EVIDENCE FOR SPECIES' DIFFERENCES IN THE EFFECT OF SERUM GAMMA-GLOBULIN CONCENTRATION ON GAMMA-GLOBULIN CATABOLISM.

Authors:  S SELL
Journal:  J Exp Med       Date:  1964-11-01       Impact factor: 14.307
View more
  12 in total

1.  Familial hypercatabolic hypoproteinemia. A disorder of endogenous catabolism of albumin and immunoglobulin.

Authors:  T A Waldmann; W D Terry
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

2.  [The variation of 16 serum protein fractions following renal transplantation (author's transl)].

Authors:  C Marone; W Flury; A Montandon; H Keller
Journal:  Klin Wochenschr       Date:  1978-07-01

3.  Polyvalent immunoglobulins for prophylaxis of bacterial infections in patients following multiple trauma. A randomized, placebo-controlled study.

Authors:  W Glinz; P J Grob; U E Nydegger; T Ricklin; F Stamm; D Stoffel; A Lasance
Journal:  Intensive Care Med       Date:  1985       Impact factor: 17.440

4.  Secondary Antibody Deficiency in Glucocorticoid Therapy Clearly Differs from Primary Antibody Deficiency.

Authors:  Clemens Wirsum; Cornelia Glaser; Sylvia Gutenberger; Baerbel Keller; Susanne Unger; Reinhard E Voll; Werner Vach; Thomas Ness; Klaus Warnatz
Journal:  J Clin Immunol       Date:  2016-03-15       Impact factor: 8.317

5.  Development of orally active inhibitors of protein and cellular fucosylation.

Authors:  Nicole M Okeley; Stephen C Alley; Martha E Anderson; Tamar E Boursalian; Patrick J Burke; Kim M Emmerton; Scott C Jeffrey; Kerry Klussman; Che-Leung Law; Django Sussman; Brian E Toki; Lori Westendorf; Weiping Zeng; Xinqun Zhang; Dennis R Benjamin; Peter D Senter
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-14       Impact factor: 11.205

6.  Effects of corticosteroids on immunity in man. I. Decreased serum IgG concentration caused by 3 or 5 days of high doses of methylprednisolone.

Authors:  W T Butler; R D Rossen
Journal:  J Clin Invest       Date:  1973-10       Impact factor: 14.808

7.  Corticosteroid treatment increases parasite numbers in murine giardiasis.

Authors:  K V Nair; J Gillon; A Ferguson
Journal:  Gut       Date:  1981-06       Impact factor: 23.059

8.  The relationship between L-chain synthesis and gamma-globulin production.

Authors:  C Waterhouse; G Abraham; J Vaughan
Journal:  J Clin Invest       Date:  1973-05       Impact factor: 14.808

9.  Hypercatabolism of IgG, IgA, IgM, and albumin in the Wiskott-Aldrich syndrome. A unique disorder of serum protein metabolism.

Authors:  R M Blaese; W Strober; A L Levy; T A Waldmann
Journal:  J Clin Invest       Date:  1971-11       Impact factor: 14.808

10.  Metabolism of IgG in type II mixed essential cryoglobulinaemia--autologous cryoprecipitated and normal homologous IgG are incorporated into complexes and metabolized in vivo at similar rates.

Authors:  J A Schifferli; N Amos; C D Pusey; J G Sissons; D K Peters
Journal:  Clin Exp Immunol       Date:  1983-02       Impact factor: 4.330
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.