Literature DB >> 4192620

Hapten-carrier relationships of isoantigens. A model for immunological maturation based on the conversion of haptens of carriers by antibody.

R A McBride, L W Schierman.   

Abstract

In chickens, erythrocyte isoantigens have hapten-carrier relationships. Specific anticarrier antibody depresses the immune response to the carrier and enhances the immune response to the hapten. Antigenic determinants of "haptenic" isoantigens behave as carriers if they are coated with specific antibody. It is postulated that every humoral antibody response involves the cooperation of a carrier with a hapten and the progressive conversion by antibody of haptens to carriers. Thus a carrier is viewed as an antigenic determinant which is coated with antibody. The antibody-forming cell only synthesizes antibody to the uncoated haptenic determinants. The consequences of this interpretation for the development of immunological maturity and the secondary immune response are discussed.

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Year:  1970        PMID： 4192620      PMCID： PMC2138793          DOI： 10.1084/jem.131.2.377

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  28 in total

1.  Further experimental studies on the prevention of Rh haemolytic disease.

Authors:  C A CLARKE; W T DONOHOE; R B McCONNELL; J C WOODROW; R FINN; J R KREVANS; W KULKE; D LEHANE; P M SHEPPARD
Journal:  Br Med J       Date:  1963-04-13

2.  Enhanced sensitization in mice by simultaneous injection of antigen and specific rabbit antiserum.

Authors:  G TERRES; W WOLINS
Journal:  Proc Soc Exp Biol Med       Date:  1959 Oct-Dec

3.  The formation of immunoglobulins by human tissues in vitro. IV. Circulating lymphocytes in normal and pathological conditions.

Authors:  R van Furth; H R Schuit; W Hijmans
Journal:  Immunology       Date:  1966-07       Impact factor: 7.397

4.  Suppression of synthesis of allotypically defined immunoglobulins and compensation by another sub-class of immunoglobulin.

Authors:  S Dubiski
Journal:  Nature       Date:  1967-06-24       Impact factor: 49.962

5.  HOMEOSTASIS OF ANTIBODY FORMATION IN THE ADULT RAT.

Authors:  D A ROWLEY; F W FITCH
Journal:  J Exp Med       Date:  1964-12-01       Impact factor: 14.307

6.  The immune response to a hybrid protein molecule; specificity of secondary stimulation and of tolerance induction.

Authors:  K Rajewsky; E Rottländer; G Peltre; B Müller
Journal:  J Exp Med       Date:  1967-10-01       Impact factor: 14.307

7.  The requirement of more than one antigenic determinant for immunogenicity.

Authors:  K Rajewsky; V Schirrmacher; S Nase; N K Jerne
Journal:  J Exp Med       Date:  1969-06-01       Impact factor: 14.307

8.  STUDIES ON RABBIT LYMPHOCYTES IN VITRO. I. STIMULATION OF BLAST TRANSFORMATION WITH AN ANTIALLOTYPE SERUM.

Authors:  S SELL; P G GELL
Journal:  J Exp Med       Date:  1965-08-01       Impact factor: 14.307

9.  Studies on rabbit lymphocytes in vitro. V. The induction of blast transformation with sheep antisera to rabbit IgG subunits.

Authors:  S Sell
Journal:  J Exp Med       Date:  1967-02-01       Impact factor: 14.307

10.  Studies on the effect of the carrier molecule on antihapten antibody synthesis. I. Effect of carrier on the nature of the antibody synthesized.

Authors:  G W Siskind; W E Paul; B Benacerraf
Journal:  J Exp Med       Date:  1966-04-01       Impact factor: 14.307
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  10 in total

Review 1.  The role of antibody in T-cell responses.

Authors:  J H Playfair
Journal:  Clin Exp Immunol       Date:  1974-05       Impact factor: 4.330

Review 2.  Structure and properties of the major histocompatibility complex of the chicken. Speculations on the advantages and evolution of polymorphism.

Authors:  B M Longenecker; T R Mosmann
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

Review 3.  Major histocompatibility complex of chickens: genes, antigens, differential features, and special contributions to our knowledge of the advantages of polymorphism of cell surface antigens.

Authors:  B M Longenecker
Journal:  Surv Immunol Res       Date:  1982

4.  Determination of antibody class in a system of cooperating antigenic determinants.

Authors:  V Schirrmacher; K Rajewsky
Journal:  J Exp Med       Date:  1970-11       Impact factor: 14.307

5.  Passive antibody and the immune response. Factors which determine enhancement and suppression.

Authors:  R A McBride; L W Schierman
Journal:  J Exp Med       Date:  1971-10-01       Impact factor: 14.307

6.  Antigen-dependent IgM-mediated enhancement of the sheep erythrocyte response in mice. Evidence for induction of B cells with specificities other than that of the injected antibodies.

Authors:  B Heyman; G Andrighetto; H Wigzell
Journal:  J Exp Med       Date:  1982-04-01       Impact factor: 14.307

7.  Regulation of the immune response: suppressive and enhancing effects of passively administered antibody.

Authors:  C S Pincus; M E Lamm; V Nussenzweig
Journal:  J Exp Med       Date:  1971-05-01       Impact factor: 14.307

8.  H-2-linked genetic control of immune responsiveness to ovalbumin and ovomucoid.

Authors:  N M Vaz; J M Phillips-Quagliata; B B Levine; E M Vaz
Journal:  J Exp Med       Date:  1971-11-01       Impact factor: 14.307

9.  Tolerance and autoimmunity to erythroid differentiation (B-G) major histocompatibility complex alloantigens of the chicken.

Authors:  C Havele; T G Wegmann; B M Longenecker
Journal:  J Exp Med       Date:  1982-08-01       Impact factor: 14.307

10.  Immunodeviation by passive antibody, an expression of selective immunodepression. II. Action of guinea pig IgG1 and IgG2 anticarrier antibodies.

Authors:  P Vuagnat; T Neveu; G A Voisin
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307
  10 in total

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