| Literature DB >> 4190681 |
Abstract
Total DNA and DNA from the heterochromatin and euchromatin fractions of male guinea pig liver nuclei were analyzed by cesium sulfate-silver density-gradient centrifugation. Total DNA is composed of three components: a heavy satellite DNA, a main DNA of intermediate density, and a light satellite DNA. Heterochromatin DNA shows a fourfold enrichment in the satellite components while euchromatin DNA is relatively devoid of them. The strands of both satellite DNA's are separable by centrifugation in alkaline cesium chloride. Base analyses on the separate strands demonstrate that the two satellite DNA's represent different species.Entities:
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Year: 1970 PMID: 4190681 DOI: 10.1126/science.168.3928.263
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728