Literature DB >> 418744

Mode of action of the 2-nitroimidazole derivative benznidazole.

A Polak, R Richle.   

Abstract

Using cultures of Trypanosoma cruzi cells in a liquid medium, the mode of action of the 2-nitroimidazole derivative benznidazole was examined. Benznidazole inhibits protein synthesis and RNA synthesis in T. cruzy. The DNA synthesis is only slightly decreased and no effect on the aerobic respiration of T. cruzi was observed.

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Year:  1978        PMID： 418744     DOI： 10.1080/00034983.1978.11719278

Source DB:  PubMed          Journal:  Ann Trop Med Parasitol        ISSN： 0003-4983


  10 in total

1.  Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi.

Authors:  E G Díaz de Toranzo; J A Castro; B M Franke de Cazzulo; J J Cazzulo
Journal:  Experientia       Date:  1988-10-15

2.  Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase.

Authors:  F S Buckner; C L Verlinde; A C La Flamme; W C Van Voorhis
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

3.  Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study.

Authors:  D E Perez-Mazliah; M G Alvarez; G Cooley; B E Lococo; G Bertocchi; M Petti; M C Albareda; A H Armenti; R L Tarleton; S A Laucella; R Viotti
Journal:  J Antimicrob Chemother       Date:  2012-10-26       Impact factor: 5.790

4.  Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi.

Authors:  S G Goijman; J F Turrens; G B Marini-Bettolo; A O Stoppani
Journal:  Experientia       Date:  1985-05-15

5.  Trypanosoma brucei brucei: the response to Melarsoprol in mice with cerebral trypanosomiasis. An immunopathological study.

Authors:  A A Poltera; A Hochmann; P H Lambert
Journal:  Clin Exp Immunol       Date:  1981-11       Impact factor: 4.330

6.  Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.

Authors:  Andrea Trochine; Darren J Creek; Paula Faral-Tello; Michael P Barrett; Carlos Robello
Journal:  PLoS Negl Trop Dis       Date:  2014-05-22

7.  Aptamer-based detection of disease biomarkers in mouse models for chagas drug discovery.

Authors:  Fernanda Fortes de Araujo; Rana Nagarkatti; Charu Gupta; Ana Paula Marino; Alain Debrabant
Journal:  PLoS Negl Trop Dis       Date:  2015-01-08

8.  Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection.

Authors:  Juliana Magalhães Chaves Barbosa; Yasmin Pedra Rezende; Tatiana Galvão de Melo; Gabriel de Oliveira; Cynthia Machado Cascabulho; Evelyn Nunes Goulart da Silva Pereira; Anissa Daliry; Kelly Salomão Salem
Journal:  Microbiol Spectr       Date:  2022-02-09

9.  Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in Trypanosoma cruzi-infected cardiac cells.

Authors:  Juliana Magalhães Chaves Barbosa; Yasmin Pedra-Rezende; Luíza Dantas Pereira; Tatiana Galvão de Melo; Helene Santos Barbosa; Joseli Lannes-Vieira; Solange Lisboa de Castro; Anissa Daliry; Kelly Salomão
Journal:  Front Cell Infect Microbiol       Date:  2022-08-25       Impact factor: 6.073

10.  Induction of resistance to azole drugs in Trypanosoma cruzi.

Authors:  F S Buckner; A J Wilson; T C White; W C Van Voorhis
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191
  10 in total

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